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. 2025 Mar 20;188(6):1746-1746.e1.
doi: 10.1016/j.cell.2025.01.001.

SnapShot: Human sperm-egg interface proteins

Emily Forster  1 , Xinyin Wang  1 , Abenan Thayaparan  1 , Jeffrey E Lee  2
Affiliations

SnapShot: Human sperm-egg interface proteins

Emily Forster et al. Cell. .

Abstract

Human fertilization is a complex, highly regulated process that involves intricate molecular interactions between sperm and egg. Ultimately, this process culminates in the fusion of the gamete membranes to form a zygote. Gene disruption studies in mice have identified several critical fertilization factors. This SnapShot highlights the structure function of key proteins at the sperm-egg interface, providing insights into the mechanism of fertilization. To view this SnapShot, open or download the PDF.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

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