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Review
. 2025 Jun;16(6):581-591.
doi: 10.1080/20415990.2025.2483151. Epub 2025 Mar 21.

Advantages and therapeutic applications of different semisolids as vehicles for nano-based systems

Eman Samy Shalaby  1 , Samy I Shalaby  2 , Shaymaa A Ismail  3
Affiliations
Review

Advantages and therapeutic applications of different semisolids as vehicles for nano-based systems

Eman Samy Shalaby et al. Ther Deliv. 2025 Jun.

Abstract

The aim of this review is to highlight the role of semisolid systems as vehicles for nanovesicles and nanoparticles. In general, nanotechnology plays a critical role in facilitating the delivery of therapeutic agents to their active sites, and several nanocarrier systems have been explored for the topical administration of active components. The major disadvantage of the prepared nanosystems is their low viscosity, which reduces the time needed for enough absorption and negatively affects their stability and bioavailability. The role of semisolid systems is to overcome this limitation. In conclusion, this review presents an updated summary of recent advances in the use of semisolids as vehicles for various nanosystems through comprehensive scrutiny of the types of semisolids and their advantages and their role in enhancing the absorption of nanoparticles and nanovesicles.

Keywords: Semisolid systems; drug delivery; nanoparticles; nanotechnology; nanovesicles.

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Conflict of interest statement

The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.

No writing assistance was utilized in the production of this manuscript.

References

    1. Sousa F, Ferreira D, Reis S, et al. Current insights on antifungal therapy: novel nanotechnology approaches for drug delivery systems and new drugs from natural sources. Pharmaceuticals. 2020;13(9):248. doi: 10.3390/ph13090248 - DOI - PMC - PubMed
    1. Petrovic S, Bita B, Barbinta-Patrascu M-E.. Nanoformulations in pharmaceutical and biomedical applications: green perspectives. Int J Mol Sci. 2024;25(11):5842. doi: 10.3390/ijms25115842 - DOI - PMC - PubMed

    2. • Gives insight into the nanoformulations reported in the literature.

    1. Sari MHM, Ferreira LM, Cruz L.. The use of natural gums to produce nano-based hydrogels and films for topical application. Int J Pharm. 2022;626:122166. doi: 10.1016/j.ijpharm.2022.122166 - DOI - PubMed
    1. Herbig ME, Evers D-H, Gorissen S, et al. Rational design of topical semi-solid dosage forms-how far are we? Pharmaceutics. 2023;15(7):1822. doi: 10.3390/pharmaceutics15071822 - DOI - PMC - PubMed

    2. •• Provide insight into the future of topical semisolid preparations.

    1. Majerič P, Jović Z, Švarc T, et al. Physicochemical properties of gold nanoparticles for skin care creams. Mat. 2023;16(8):3011. doi: 10.3390/ma16083011 - DOI - PMC - PubMed

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