Retraction Note: Target receptor identification and subsequent treatment of resected brain tumors with encapsulated and engineered allogeneic stem cells

Deepak Bhere^{1

2

3}, Sung Hugh Choi^{1

2}, Pim van de Donk^{1

4}, David Hope^{1

2}, Kiki Gortzak^{1

4}, Amina Kunnummal^{1

4}, Jasneet Khalsa^{1

2}, Esther Revai Lechtich^{1

2}, Clemens Reinshagen^{1

2}, Victoria Leon^{1

2}, Nabil Nissar^{1

4}, Wenya Linda Bi², Cheng Feng⁵, Hongbin Li⁵, Yu Shrike Zhang⁵, Steven H Liang⁴, Neil Vasdev⁴, Walid Ibn Essayed², Pablo Valdes Quevedo², Alexandra Golby², Naima Banouni⁶, Anna Palagina⁷, Reza Abdi⁶, Brian Fury⁸, Stelios Smirnakis⁷, Alarice Lowe^{9

10}, Brock Reeve¹¹, Arthur Hiller¹², E Antonio Chiocca², Glenn Prestwich^{13

14}, Hiroaki Wakimoto^{1

2

15}, Gerhard Bauer⁸, Khalid Shah^{16

17

18}

Affiliations

¹ Center for Stem Cell and Translational Immunotherapy (CSTI), Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
² Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
³ Department of Pathology, Microbiology, and Immunology, University of South Carolina School of Medicine, Columbia, SC, USA.
⁴ Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
⁵ Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
⁶ Department of Renal Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
⁷ Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
⁸ UC Davis Institute for Regenerative Cures, Davis, CA, USA.
⁹ Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
¹⁰ Department of Pathology, Stanford University, Stanford, CA, USA.
¹¹ Harvard Stem Cell Institute, Harvard University, Cambridge, MA, USA.
¹² Amasa Therapeutics Inc., 1 Harmony Lane, Andover, MA, USA.
¹³ Department of Medicinal Chemistry, College of Pharmacy University of Utah, Salt Lake City, UT, USA.
¹⁴ Washington State University Health Sciences, Spokane, WA, USA.
¹⁵ Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
¹⁶ Center for Stem Cell and Translational Immunotherapy (CSTI), Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. kshah@bwh.harvard.edu.
¹⁷ Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. kshah@bwh.harvard.edu.
¹⁸ Harvard Stem Cell Institute, Harvard University, Cambridge, MA, USA. kshah@bwh.harvard.edu.

PMID: 40118851
PMCID: PMC11928485
DOI: 10.1038/s41467-025-57909-0

Retraction Note: Target receptor identification and subsequent treatment of resected brain tumors with encapsulated and engineered allogeneic stem cells

Deepak Bhere et al. Nat Commun. 2025.

. 2025 Mar 21;16(1):2803.

doi: 10.1038/s41467-025-57909-0.

Authors

Affiliations

¹ Center for Stem Cell and Translational Immunotherapy (CSTI), Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
² Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
³ Department of Pathology, Microbiology, and Immunology, University of South Carolina School of Medicine, Columbia, SC, USA.
⁴ Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
⁵ Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
⁶ Department of Renal Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
⁷ Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
⁸ UC Davis Institute for Regenerative Cures, Davis, CA, USA.
⁹ Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
¹⁰ Department of Pathology, Stanford University, Stanford, CA, USA.
¹¹ Harvard Stem Cell Institute, Harvard University, Cambridge, MA, USA.
¹² Amasa Therapeutics Inc., 1 Harmony Lane, Andover, MA, USA.
¹³ Department of Medicinal Chemistry, College of Pharmacy University of Utah, Salt Lake City, UT, USA.
¹⁴ Washington State University Health Sciences, Spokane, WA, USA.
¹⁵ Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
¹⁶ Center for Stem Cell and Translational Immunotherapy (CSTI), Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. kshah@bwh.harvard.edu.
¹⁷ Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. kshah@bwh.harvard.edu.
¹⁸ Harvard Stem Cell Institute, Harvard University, Cambridge, MA, USA. kshah@bwh.harvard.edu.

PMID: 40118851
PMCID: PMC11928485
DOI: 10.1038/s41467-025-57909-0

No abstract available

PubMed Disclaimer

Retraction of

Target receptor identification and subsequent treatment of resected brain tumors with encapsulated and engineered allogeneic stem cells.
Bhere D, Choi SH, van de Donk P, Hope D, Gortzak K, Kunnummal A, Khalsa J, Revai Lechtich E, Reinshagen C, Leon V, Nissar N, Bi WL, Feng C, Li H, Zhang YS, Liang SH, Vasdev N, Essayed W, Quevedo PV, Golby A, Banouni N, Palagina A, Abdi R, Fury B, Smirnakis S, Lowe A, Reeve B, Hiller A, Chiocca EA, Prestwich G, Wakimoto H, Bauer G, Shah K. Bhere D, et al. Nat Commun. 2022 May 19;13(1):2810. doi: 10.1038/s41467-022-30558-3. Nat Commun. 2022. Retraction in: Nat Commun. 2025 Mar 21;16(1):2803. doi: 10.1038/s41467-025-57909-0. PMID: 35589724 Free PMC article. Retracted.

References

1. Elrod, H. A. et al. Analysis of death receptor 5 and caspase-8 expression in primary and metastatic head and neck squamous cell carcinoma and their prognostic impact. PLoS One5, e12178 (2010). - PMC - PubMed
1. Bhere, D. et al. microRNA-7 upregulates death receptor 5 and primes resistant brain tumors to caspase-mediated apoptosis. Neuro Oncol.20, 215–224 (2018). - PMC - PubMed
1. https://www.fishersci.com/shop/products/mouse-rat-butyrylcholinesterase-..., accessed 14 October 2024.
1. Kindy, M. S., Yu, J., Zhu, H., Smith, M. T. & Gattoni-Celli, S. A therapeutic cancer vaccine against GL261 murine glioma. J. Transl. Med.14, 1 (2016). - PMC - PubMed
1. https://sciencellonline.com/human-bone-marrow-derived-mesenchymal-stem-c..., accessed 14 October 2024.

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Retraction Note: Target receptor identification and subsequent treatment of resected brain tumors with encapsulated and engineered allogeneic stem cells

Affiliations

Retraction Note: Target receptor identification and subsequent treatment of resected brain tumors with encapsulated and engineered allogeneic stem cells

Authors

Affiliations

Retraction of

References

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