Radiological diagnosis of acute mesenteric ischemia in adult patients: a systematic review and meta-analysis

Abstract

Computed tomography (CT) is widely used in diagnosing acute mesenteric ischemia (AMI), but robust identification of distinctive subtypes and stages of progression is lacking. Systematic literature search in PubMed, Cochrane Library, Web of Science and Scopus was conducted in May 2024. Studies including at least 10 adult patients and reporting radiological diagnosis of AMI versus no AMI or transmural ischemia versus no transmural ischemia were included. Meta-analyses on sensitivity and specificity of different radiological features in diagnosing AMI were conducted. From 2628 titles, 490 studies underwent full text review, and 81 were included in 14 meta-analyses. Diagnostic accuracy of CT angiography (CTA) was high - sensitivity of 92.0% and specificity of 98.8% (I² 45% and 79%, respectively), but lower for other CT protocols (sensitivity 75.8 and specificity 90.5; I² 83%). In most included studies, distinction of subtypes and severity of AMI (non-transmural or transmural) was not possible. Amongst the non-vascular features, absent/reduced bowel wall enhancement provided the best prognostic value (sensitivity 57.9 and specificity 90.1). CTA is the method of choice for diagnosing AMI with high diagnostic accuracy. None of the non-vascular features alone is sufficiently reliable to diagnose AMI or its progression to transmural necrosis, whereas a combination of different radiological features conveys a potential.

Keywords: Acute mesenteric ischemia; Adult; Computed tomography; Diagnostic accuracy; Radiology.

Fig. 1

Flow diagram.

Fig. 2

Accuracy of diagnosis of AMI with composite radiological assessment.

Fig. 3

Diagnostic accuracy of absent or reduced bowel wall enhancement.

Fig. 4

Diagnostic accuracy of mesenteric signs (stranding, edema, effusion).

Fig. 5

Diagnostic accuracy of ascites.

Fig. 6

Diagnostic accuracy of bowel wall thickening.