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. 2025 Nov;80(11):3178-3180.
doi: 10.1111/all.16533. Epub 2025 Mar 22.

Allergic Signature in Delayed Cross-Hypersensitivity to all Iodinated Contrast Media

D Do  1 , L Bertolotti  1 , A Mosnier  2 , A Facile  3 , V Bourdenet  1 , N Poletto  4 , A Guironnet-Paquet  2 , F Hacard  1   2 , A Nosbaum  1   2 , F Bérard  1   2 , J-F Nicolas  1   2 , M Vocanson  2 , M-A Lefevre  2   5 , M Tauber  1   2
Affiliations

Allergic Signature in Delayed Cross-Hypersensitivity to all Iodinated Contrast Media

D Do et al. Allergy. 2025 Nov.
No abstract available

Keywords: allergy diagnosis; drug allergy; immunologic tests; iodinated contrast media.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

FIGURE 1
FIGURE 1
Initial reaction and allergy test results. Maculopapular exanthema on the front (A) and back (B) of the trunk 3 days after iomeprol infusion. Intradermal positive skin test at 72 h for (C) iohexol (1), iopamidol (2), iomeprol (3), iobitridol (4) and (D) iodixanol (5), ioversol (6) and iopromide (7).
FIGURE 2
FIGURE 2
Molecular Analysis of Positive Intradermal Tests and Lymphocyte Transformation Test. (A) Total RNA was extracted from skin biopsies, and gene expression of CD8A, CD4, GLNY, GZMB, CD69, IFNG, CXCL10, HLA‐DRA, GPR183, PLEK, IL‐15, and IGFL3 was analyzed by qRT‐PCR. Expression values were normalized to GAPDH. Results are expressed as fold changes relative to control skin. Und, Undetected (B) Patient peripheral blood mononuclear cells were isolated by Ficoll density gradient centrifugation and exposed to varying concentrations of the tested drugs or control drug (amoxicillin). Negative (drug‐free, white bar) and positive (non‐specific activators, gray bars) controls ensured experimental reliability. T lymphocyte proliferation was measured by [3H]thymidine incorporation; results are expressed as the proliferation index (ratio of 3H in drug‐stimulated to unstimulated cells). Three healthy donor controls were tested negative for iomeprol and iodixanol (five increasing drug concentrations respectively, not shown).
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