Standard: human liver-on-a-chip

Haitao Liu^#¹, Xu Zhang^#¹, Yaqing Wang^{2

3}, Min Zhang¹, Peng Wang^{2

3}, Jing Shang⁴, Zhongqiang Li⁵, Likun Gong⁶, Xin Xie⁶, Dongyang Liu⁷, Jingbo Pi⁸, Xinghua Gao⁹, Xianliang Li¹⁰, Wei Ding¹¹, Dianbing Wang¹², Yun Long¹³, Lan Wang¹⁴, Song Li¹⁵, Xingchao Geng¹⁶, Pingkun Zhou¹⁷, Wanjin Tang⁵, Xian'en Zhang¹⁸, Chunying Chen¹⁹, Shengli Yang¹, Jianhua Qin^{20

21}

Affiliations

¹ Division of Biotechnology, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, China.
² University of Science and Technology of China, Hefei, China.
³ Suzhou Institute for Advanced Research, University of Science and Technology of China, Suzhou, China.
⁴ China Pharmaceutical University, Nanjing, China.
⁵ China National Institute of Standardization, Beijing, China.
⁶ Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.
⁷ Peking University Third Hospital, Beijing, China.
⁸ China Medical University, Shenyang, China.
⁹ Shanghai University, Shanghai, China.
¹⁰ Department of HBP Surgery, Beijing Chao Yang Hospital, the Capital Medical University, Beijing, China.
¹¹ SPH KDL Health Beijing, Shanghai Pharma, Beijing, China.
¹² Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.
¹³ Peking Union Medical College Hospital, Beijing, China.
¹⁴ Dalian Xin'en Medical Technology Co., LTD, Dalian, China.
¹⁵ Institute of Pharmacology and Toxicology, Academy of Military Medical Science, Beijing, China.
¹⁶ National Institutes for Food and Drug Control, Beijing, China.
¹⁷ Institute of Radiation Medicine, Chinese Academy of Medical Sciences, Tianjin, China.
¹⁸ Shenzhen University of Advanced Technology, Shenzhen, China.
¹⁹ National Center for Nanoscience and Technology, Beijing, China.
²⁰ Division of Biotechnology, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, China. jhqin@dicp.ac.cn.
²¹ Beijing Institute for Stem Cell and Regenerative Medicine, Beijing, China. jhqin@dicp.ac.cn.

^# Contributed equally.

PMID: 40123019
PMCID: PMC11930896
DOI: 10.1186/s13619-025-00226-0

Editorial

Standard: human liver-on-a-chip

Haitao Liu et al. Cell Regen. 2025.

. 2025 Mar 24;14(1):9.

doi: 10.1186/s13619-025-00226-0.

Authors

Affiliations

¹ Division of Biotechnology, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, China.
² University of Science and Technology of China, Hefei, China.
³ Suzhou Institute for Advanced Research, University of Science and Technology of China, Suzhou, China.
⁴ China Pharmaceutical University, Nanjing, China.
⁵ China National Institute of Standardization, Beijing, China.
⁶ Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.
⁷ Peking University Third Hospital, Beijing, China.
⁸ China Medical University, Shenyang, China.
⁹ Shanghai University, Shanghai, China.
¹⁰ Department of HBP Surgery, Beijing Chao Yang Hospital, the Capital Medical University, Beijing, China.
¹¹ SPH KDL Health Beijing, Shanghai Pharma, Beijing, China.
¹² Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.
¹³ Peking Union Medical College Hospital, Beijing, China.
¹⁴ Dalian Xin'en Medical Technology Co., LTD, Dalian, China.
¹⁵ Institute of Pharmacology and Toxicology, Academy of Military Medical Science, Beijing, China.
¹⁶ National Institutes for Food and Drug Control, Beijing, China.
¹⁷ Institute of Radiation Medicine, Chinese Academy of Medical Sciences, Tianjin, China.
¹⁸ Shenzhen University of Advanced Technology, Shenzhen, China.
¹⁹ National Center for Nanoscience and Technology, Beijing, China.
²⁰ Division of Biotechnology, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, China. jhqin@dicp.ac.cn.
²¹ Beijing Institute for Stem Cell and Regenerative Medicine, Beijing, China. jhqin@dicp.ac.cn.

^# Contributed equally.

PMID: 40123019
PMCID: PMC11930896
DOI: 10.1186/s13619-025-00226-0

Abstract

Organs-on-chips are microphysiological systems designed to replicate key functions of human organs, thereby accelerating innovation in life sciences, such as disease modeling, drug development, and precision medicine. However, the lack of standardized definitions, structural designs, cell sources, model constructions, and functional validations has posed challenges to their widespread translational applications. On April 29, 2024, the Chinese Society of Biotechnology introduced "Organs-on-chips: Liver", China's first group standard for human liver-on-a-chip technology. This pioneering standard provides comprehensive guidelines, including scope, terminology, definitions, technical requirements, detection methods, and quality control measures for developing liver models on chips. The introduction of this standard is set to facilitate the establishment of institutional protocols, promote widespread adoption, and drive the international standardization of liver-on-a-chip technologies.

Keywords: Liver-on-a-chip; Microphysiological system; Organs-on-chips; Standard.

PubMed Disclaimer

Conflict of interest statement

Declarations. Ethics approval and consent to participate: Not applicable. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests.

References

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Standard: human liver-on-a-chip

Affiliations

Standard: human liver-on-a-chip

Authors

Affiliations

Abstract

Conflict of interest statement

References

Publication types

LinkOut - more resources

Full Text Sources