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. 2025 May 1;53(5):e1163-e1165.
doi: 10.1097/CCM.0000000000006640. Epub 2025 Mar 24.

A Salty Start to Resuscitation: Does It Matter?

Mujtaba Mahmud  1   2 , Susan E Hamblin  3
Affiliations

A Salty Start to Resuscitation: Does It Matter?

Mujtaba Mahmud et al. Crit Care Med. .
No abstract available

Keywords: balanced fluid; crystalloid; lactated Ringer’s; resuscitation; saline; sepsis.

PubMed Disclaimer

Conflict of interest statement

Dr. Hamblin’s institution received funding from Prytime Medical Devices. Dr. Mahmud disclosed that he did not have any potential conflicts of interest.

References

    1. Semler MW, Self WH, Wanderer JP, et al.; SMART Investigators and the Pragmatic Critical Care Research Group: Balanced crystalloids versus saline in critically Ill adults. N Engl J Med. 2018; 378:829–839
    1. Brown RM, Wang L, Coston TD, et al.: Balanced crystalloids versus saline in sepsis. A secondary analysis of the SMART clinical trial. Am J Respir Crit Care Med. 2019; 200:1487–1495
    1. Evans L, Rhodes A, Alhazzani W, et al.: Surviving sepsis campaign: International guidelines for management of sepsis and septic shock 2021. Intensive Care Med. 2021; 47:1181–1247
    1. Beran A, Altorok N, Srour O, et al.: Balanced crystalloids versus normal saline in adults with sepsis: A comprehensive systematic review and meta-analysis. J Clin Med. 2022; 11:1971
    1. Zampieri FG, Machado FR, Biondi RS, et al.: Effects of intravenous fluid treatment with a balanced solution vs 0.9% saline solution in mortality in critically ill patients: The BaSICS randomized clinical trial. JAMA. 2021; 326:818–829

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