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Editorial
. 2025 Jun;211(6):899-901.
doi: 10.1164/rccm.202501-0098ED.

"Diamonds Are Forever": Novel Vascular Endothelial Growth Factor-Nanodiamond Therapy for the Treatment of Congenital Diaphragmatic Hernia

Andreas Damianos  1   2 , Bernard Thébaud  3   4   5 , Vladimir V Kalinichenko  1   2
Affiliations
Editorial

"Diamonds Are Forever": Novel Vascular Endothelial Growth Factor-Nanodiamond Therapy for the Treatment of Congenital Diaphragmatic Hernia

Andreas Damianos et al. Am J Respir Crit Care Med. 2025 Jun.
No abstract available

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Figures

Figure 1.
Figure 1.
During normal branching morphogenesis, acinar formation leads to mature alveoli with thin secondary septation, capillaries in close proximity to the alveolar epithelium (A). In cases of congenital diaphragmatic hernia (CDH), lungs exhibit alveolar reduction, septal and interstitial thickening, and remodeling of the pulmonary vessels (B). Treatment with vascular endothelial growth factor–conjugated ND-VEGF compliment TO in mouse and rabbit models of CDH, rescuing the lung phenotypes. The treated lungs consist of alveoli that appear nearly normal, with significantly reduced vascular remodeling (C). Alv. = alveolar; AT I = alveolar Type I cells; AT II = alveolar Type II cells; Musc. = muscularized; ND = nanodiamonds; Pulm. = pulmonary; RBC = red blood cell; TO = tracheal occlusion; VEGF = vascular endothelial growth factor. Created in BioRender (https://BioRender.com/v48g669).
See this image and copyright information in PMC

Comment on

  • Prenatal VEGF Nanodelivery Reverses Congenital Diaphragmatic Hernia-associated Pulmonary Abnormalities.
    Loukogeorgakis SP, Michielin F, Al-Juffali N, Jimenez J, Shibuya S, Allen-Hyttinen J, Eastwood MP, Alhendi ASN, Davidson J, Naldi E, Maghsoudlou P, Tedeschi A, Khalaf S, Platé M, Fachin C, Dos Santos Dias A, Sindhwani N, Scaglioni D, Xenakis T, Sebire N, Giomo M, Eaton S, Toelen J, Luni C, Pavan P, Carmeliet P, Russo F, Janes S, Nikolić MZ, Elvassore N, Deprest J, De Coppi P. Loukogeorgakis SP, et al. Am J Respir Crit Care Med. 2025 Jun;211(6):992-1006. doi: 10.1164/rccm.202401-0161OC. Am J Respir Crit Care Med. 2025. PMID: 39965074

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