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Case Reports
. 2025 Feb 7:58:74-76.
doi: 10.1016/j.jdcr.2024.12.040. eCollection 2025 Apr.

Atypical bullous systemic lupus erythematosus with features of linear IgA bullous dermatosis

Roy Jiang  1 , Amanda G Zhou  1 , Christine J Ko  1 , Michael Girardi  1 , Ailish Hanly  1 , Catherine Xie  1 , Ana Preda-Naumescu  1 , Jeffrey R Gehlhausen  1 , Mary M Tomayko  1   2
Affiliations
Case Reports

Atypical bullous systemic lupus erythematosus with features of linear IgA bullous dermatosis

Roy Jiang et al. JAAD Case Rep. .
No abstract available

Keywords: bullous SLE; immunobullous disorder; linear IgA dermatosis.

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Conflict of interest statement

None disclosed.

Figures

Fig 1
Fig 1
Initial presentation. (A) Exam findings on initial presentation of scattered vesicles and bullae on pink pruritic plaques over the back. (B) Initial H&E of skin biopsy sample showing subepidermal acantholysis and neutrophilic infiltrate at the DEJ. DEJ, Dermal-epidermal junction.
Fig 2
Fig 2
IgA immunofluorescence studies. (A) DIF showing linear IgA deposition along DEJ. (B) Dermal side IgA staining on DIF performed on SSS processed initial skin biopsy sample. DEJ, Dermal-epidermal junction; DIF, direct immunofluorescence; SSS, salt split skin.
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References

    1. Becker M., Schumacher N., Schmidt E., Zillikens D., Sadik C.D. Evaluation and comparison of clinical and iLaboratory characteristics of patients with IgA epidermolysis bullosa acquisita, linear IgA bullous dermatosis, and IgG epidermolysis bullosa acquisita. JAMA Dermatol. 2021;157(8):917–923. doi: 10.1001/jamadermatol.2021.0762. - DOI - PMC - PubMed
    1. Chanprapaph K., Sawatwarakul S., Vachiramon V. A 12-year retrospective review of bullous systemic lupus erythematosus in cutaneous and systemic lupus erythematosus patients. Lupus. 2017;26(12):1278–1284. doi: 10.1177/0961203317699714. - DOI - PubMed
    1. de Risi-Pugliese T., Cohen Aubart F., Haroche J., et al. Clinical, histological, immunological presentations and outcomes of bullous systemic lupus erythematosus: 10 New cases and a literature review of 118 cases. Semin Arthritis Rheum. 2018;48(1):83–89. doi: 10.1016/j.semarthrit.2017.11.003. - DOI - PubMed
    1. Guide S.V., Marinkovich M.P. Linear IgA bullous dermatosis. Clin Dermatol. 2001;19(6):719–727. doi: 10.1016/S0738-081X(00)00185-1. - DOI - PubMed
    1. Ting W., Stone M.S., Racila D., Scofield R.H., Sontheimer R.D. Toxic epidermal necrolysis-like acute cutaneous lupus erythematosus and the spectrum of the acute syndrome of apoptotic pan-epidermolysis (ASAP): a case report, concept review and proposal for new classification of lupus erythematosus vesiculobullous skin lesions. Lupus. 2004;13(12):941–950. doi: 10.1191/0961203304lu2037sa. - DOI - PubMed

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