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. 2025 Jun;56(2):1103-1115.
doi: 10.1007/s42770-025-01658-1. Epub 2025 Mar 25.

Anellovirus species in the serum of acute febrile patients from Mato Grosso, central Western Brazil, 2019

Eduarda Pavan  1 , Janeth Aracely Ramirez Pavón  2 , Márcio Roberto Teixeira Nunes  3 , Millena Moreira Carrasco  4   5 , Marcelo Adriano Mendes Dos Santos  2   3 , Renata Dezengrini Slhessarenko  6   7
Affiliations

Anellovirus species in the serum of acute febrile patients from Mato Grosso, central Western Brazil, 2019

Eduarda Pavan et al. Braz J Microbiol. 2025 Jun.

Abstract

The Anelloviridae family is one of the most diverse group of viruses within human virome, comprising 155 species distributed across 30 genera, four of which infect humans. Using a metagenomic approach to examine the frequency and diversity of viruses in the serum of patients with acute febrile illness in Mato Grosso during 2019, we identified and characterized two complete, three nearly complete and nine partial anellovirus genomes, including eleven putatively new species. Alphatorquevirus was the most prevalent genus (50%; n = 7), followed by Gammatorquevirus (35.7%; n = 5) and Betatorquevirus (14.3%; n = 2), consistent with global reports showing its dominance within Anelloviridae. Additionally, 65% of genomes were recovered from children, supporting higher anellovirus diversity and load in younger individuals.

Keywords: Anelloviridae; Anellovirus; Metagenomic; Viral diversity.

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Conflict of interest statement

Declarations. Competing interest: The authors declare no conflict of interest.

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