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. 2025 Mar 24;60(6):817-818.
doi: 10.1016/j.devcel.2025.02.014.

Evolving insights into pancreatic tumor initiation and progression through DCLK1-expressing tuft cells

Landon L Moore  1 , Courtney W Houchen  2
Affiliations

Evolving insights into pancreatic tumor initiation and progression through DCLK1-expressing tuft cells

Landon L Moore et al. Dev Cell. .

Abstract

In this issue of Developmental Cell, Salas-Escabillas et al. find that tuft cells undergo a tuft-to-neuroendocrine transition, switching from tumor suppressors to tumor promoters via c-Myc in pancreatic ductal adenocarcinoma (PDAC). This result offers exciting insights into PDAC's aggressiveness, therapy resistance, and high mortality.

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Conflict of interest statement

Declaration of interests C.W.H has an ownership interest in COARE Holdings, Inc.

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