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. 2025 Apr;31(4):861-863.
doi: 10.3201/eid3104.241214.

Coxiella burnetii Infections Identified by Molecular Methods, United States, 2006-2023

Caroline K Maki, Thao T Truong, Johanna S Salzer, Nicolette Bestul, Brad T Cookson, Gilbert J Kersh, Stephen J Salipante, Joshua A Lieberman, David W McCormick

Coxiella burnetii Infections Identified by Molecular Methods, United States, 2006-2023

Caroline K Maki et al. Emerg Infect Dis. 2025 Apr.

Abstract

We identified 34 patients with Coxiella burnetii infection using PCR; 31 (86%) cases were diagnosed from cardiac specimens. Nearly half (15/31, 48%) of those cases were not reported to any channel of national disease surveillance, indicating substantial underreporting for diseases identified using molecular methods at noncommercial laboratories.

Keywords: Coxiella burnetii; PCR; Q fever; United States; bacteria; endocarditis; polymerase chain reaction; surveillance; zoonoses.

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References

    1. Kaufman HW, Chen Z, Radcliff J, Batterman HJ, Leake J. Q fever: an under-reported reportable communicable disease. Epidemiol Infect. 2018;146:1240–4. 10.1017/S0950268818001395 - DOI - PMC - PubMed
    1. Centers for Disease Control and Prevention. National Notifiable Diseases Surveillance System (NNDSS). Q fever (Coxiella burnetii) 2009. case definition. Updated 2021 Apr 16 [cited 2024 Feb 20]. https://ndc.services.cdc.gov/case-definitions/q-fever-2009
    1. Anderson A, Bijlmer H, Fournier PE, Graves S, Hartzell J, Kersh GJ, et al. Diagnosis and management of Q fever—United States, 2013: recommendations from CDC and the Q Fever Working Group. MMWR Recomm Rep. 2013;62(RR-03):1–30. - PubMed
    1. Centers for Disease Control and Prevention. Q fever epidemiology and statistics. Updated 2021. Aug 6 [cited 2024 Feb 20]. https://www.cdc.gov/qfever/stats/index.html
    1. Bae M, Jin CE, Park JH, Kim MJ, Chong YP, Lee SO, et al. Diagnostic usefulness of molecular detection of Coxiella burnetii from blood of patients with suspected acute Q fever. Medicine (Baltimore). 2019;98:e15724. 10.1097/MD.0000000000015724 - DOI - PMC - PubMed

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