Optimizing prostate cancer diagnosis: combining imaging modalities for tailored treatment

doi:10.1007/s00330-025-11551-y

Editorial

. 2025 Jul;35(7):4040-4042.

doi: 10.1007/s00330-025-11551-y. Epub 2025 Mar 25.

Optimizing prostate cancer diagnosis: combining imaging modalities for tailored treatment

Laura Evangelista^{1

2}, Carlo Vallone^{3

4}, Priscilla Guglielmo^{3

5}

Affiliations

¹ Department of Biomedical Science, Humanitas University, Milan, Italy. laura.evangelista@hunimed.eu.
² Nuclear Medicine Unit, IRCCS Humanitas Research Hospital, Milan, Italy. laura.evangelista@hunimed.eu.
³ Department of Biomedical Science, Humanitas University, Milan, Italy.
⁴ Department of Advanced Biomedical Sciences, University of Naples Federico II, Naples, Italy.
⁵ Nuclear Medicine Unit, Humanitas Gavazzeni, Bergamo, Italy.

PMID: 40133440
DOI: 10.1007/s00330-025-11551-y

Editorial

Optimizing prostate cancer diagnosis: combining imaging modalities for tailored treatment

Laura Evangelista et al. Eur Radiol. 2025 Jul.

. 2025 Jul;35(7):4040-4042.

doi: 10.1007/s00330-025-11551-y. Epub 2025 Mar 25.

Authors

Laura Evangelista^{1

2}, Carlo Vallone^{3

4}, Priscilla Guglielmo^{3

5}

Affiliations

¹ Department of Biomedical Science, Humanitas University, Milan, Italy. laura.evangelista@hunimed.eu.
² Nuclear Medicine Unit, IRCCS Humanitas Research Hospital, Milan, Italy. laura.evangelista@hunimed.eu.
³ Department of Biomedical Science, Humanitas University, Milan, Italy.
⁴ Department of Advanced Biomedical Sciences, University of Naples Federico II, Naples, Italy.
⁵ Nuclear Medicine Unit, Humanitas Gavazzeni, Bergamo, Italy.

PMID: 40133440
DOI: 10.1007/s00330-025-11551-y

No abstract available

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Conflict of interest statement

Compliance with ethical standards. Guarantor: The scientific guarantor of this publication is Laura Evangelista. Conflict of interest: The authors of this manuscript declare no relationships with any companies, whose products or services may be related to the subject matter of the article. Statistics and biometry: No complex statistical methods were necessary for this paper. Informed consent: Not applicable. Ethical approval: Not applicable. Study subjects or cohorts overlap: Not applicable. Methodology: Commentary

Comment on

Discordance between prostate MRI and PSMA-PET/CT: the next big challenge for primary prostate tumor assessment?
Woo S, Becker AS, Leithner D, Mayerhoefer ME, Friedman KP, Tong A, Wise DR, Taneja SS, Zelefsky MJ, Vargas HA. Woo S, et al. Eur Radiol. 2025 Jul;35(7):4043-4054. doi: 10.1007/s00330-025-11358-x. Epub 2025 Jan 24. Eur Radiol. 2025. PMID: 39853335

References

1. Woo S, Becker AS, Leithner D et al (2025) Discordance between prostate MRI and PSMA PET/CT: the next big challenge for primary prostate tumor assessment. Eur Radiol. https://doi.org/10.1007/s00330-025-11358-x
1. Liu C, Liu T, Zhang Z et al (2020) 68Ga-PSMA PET/CT combined with PET/ultrasound-guided prostate biopsy can diagnose clinically significant prostate cancer in men with previous negative biopsy results. J Nucl Med 61:1314–1319 - DOI - PubMed - PMC
1. Zhang LL, Li WC, Xu Z et al (2021) 68Ga-PSMA PET/CT targeted biopsy for the diagnosis of clinically significant prostate cancer compared with transrectal ultrasound guided biopsy: a prospective randomized single-centre study. Eur J Nucl Med Mol Imaging 48:483–492 - DOI - PubMed
1. Moore CM, Robertson NL, Arsanious N et al (2013) Image-guided prostate biopsy using magnetic resonance imaging-derived targets: a systematic review. Eur Urol 63:125–140 - DOI - PubMed
1. Pokorny MR, de Rooij M, Duncan E et al (2014) Prospective study of diagnostic accuracy comparing prostate cancer detection by transrectal ultrasound-guided biopsy versus magnetic resonance (MR) imaging with subsequent MR-guided biopsy in men without previous prostate biopsies. Eur Urol 66:22–29 - DOI - PubMed

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[1] Woo S, Becker AS, Leithner D et al (2025) Discordance between prostate MRI and PSMA PET/CT: the next big challenge for primary prostate tumor assessment. Eur Radiol. https://doi.org/10.1007/s00330-025-11358-x

[2] Woo S, Becker AS, Leithner D et al (2025) Discordance between prostate MRI and PSMA PET/CT: the next big challenge for primary prostate tumor assessment. Eur Radiol. https://doi.org/10.1007/s00330-025-11358-x

[3] Liu C, Liu T, Zhang Z et al (2020) 68Ga-PSMA PET/CT combined with PET/ultrasound-guided prostate biopsy can diagnose clinically significant prostate cancer in men with previous negative biopsy results. J Nucl Med 61:1314–1319 - DOI - PubMed - PMC

[4] Liu C, Liu T, Zhang Z et al (2020) 68Ga-PSMA PET/CT combined with PET/ultrasound-guided prostate biopsy can diagnose clinically significant prostate cancer in men with previous negative biopsy results. J Nucl Med 61:1314–1319 - DOI - PubMed - PMC

[5] Zhang LL, Li WC, Xu Z et al (2021) 68Ga-PSMA PET/CT targeted biopsy for the diagnosis of clinically significant prostate cancer compared with transrectal ultrasound guided biopsy: a prospective randomized single-centre study. Eur J Nucl Med Mol Imaging 48:483–492 - DOI - PubMed

[6] Zhang LL, Li WC, Xu Z et al (2021) 68Ga-PSMA PET/CT targeted biopsy for the diagnosis of clinically significant prostate cancer compared with transrectal ultrasound guided biopsy: a prospective randomized single-centre study. Eur J Nucl Med Mol Imaging 48:483–492 - DOI - PubMed

[7] Moore CM, Robertson NL, Arsanious N et al (2013) Image-guided prostate biopsy using magnetic resonance imaging-derived targets: a systematic review. Eur Urol 63:125–140 - DOI - PubMed

[8] Moore CM, Robertson NL, Arsanious N et al (2013) Image-guided prostate biopsy using magnetic resonance imaging-derived targets: a systematic review. Eur Urol 63:125–140 - DOI - PubMed

[9] Pokorny MR, de Rooij M, Duncan E et al (2014) Prospective study of diagnostic accuracy comparing prostate cancer detection by transrectal ultrasound-guided biopsy versus magnetic resonance (MR) imaging with subsequent MR-guided biopsy in men without previous prostate biopsies. Eur Urol 66:22–29 - DOI - PubMed

[10] Pokorny MR, de Rooij M, Duncan E et al (2014) Prospective study of diagnostic accuracy comparing prostate cancer detection by transrectal ultrasound-guided biopsy versus magnetic resonance (MR) imaging with subsequent MR-guided biopsy in men without previous prostate biopsies. Eur Urol 66:22–29 - DOI - PubMed

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Optimizing prostate cancer diagnosis: combining imaging modalities for tailored treatment

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Optimizing prostate cancer diagnosis: combining imaging modalities for tailored treatment

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