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. 2025 Mar;18(3):39-41.

Biostimulatory Fillers to Treat Post-liposuction Skin Irregularities

Stefania Guida  1 , Ilaria Proietti  2 , Claudio Conforti  3 , Carmen Cantisani  4 , Nicola Zerbinati  5 , Giovanni Pellacani  6 , Hassan Galadari  7
Affiliations

Biostimulatory Fillers to Treat Post-liposuction Skin Irregularities

Stefania Guida et al. J Clin Aesthet Dermatol. 2025 Mar.

Abstract

Background: Treatment of post-liposuction skin irregularities (PLSI), a complication of liposuction, can be challenging.

Objective: Considering the increasing request of treatment of PLSI, the aim of this study is to evaluate the efficacy and safety of CaHA diluted/hyperdiluted to PLSI.

Methods: A retrospective study on a total of eight PLSI areas in six women treated with CaHA diluted/hyperdiluted was performed. Efficacy was estimated on pictures of affected areas collected before and four months after treatment, according to the recently validated PLSI scale and Student's t-test for paired samples was performed to analyze data. Eventual adverse events were used to evaluate safety.

Results: Our results showed a statistically significant improvement of number and depth of depressions and a trend toward reduction of skin laxity.

Conclusion: This study reported the efficacy and safety of CaHA diluted/hyperdiluted for PLSI treatment. Larger studies are encouraged to support the results of this pilot study.

Keywords: PLSI scale; Post-liposuction skin irregularities; biostimulation; calcium hydroxyapatite; liposuction.

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Conflict of interest statement

DISCLOSURES: The authors report no conflicts of interest relevant to the content of this article.

Figures

FIGURE 1.
FIGURE 1.
A 38-year-old woman at A) baseline (circle, treated area) and B) 4 months after 1 session of 1:1 CaHA diluted (arrow, result in the treated area)
FIGURE 2.
FIGURE 2.
52-year-old woman at A) baseline (circle, treated area) and B) 4 months after 1 session of 1:2 CaHA hyper-diluted (arrow, result in the treated area with specific indication of the V-sign)
See this image and copyright information in PMC

References

    1. Guida S, Zerbinati N, Conforti C et al. From cellulite to post-liposuction skin irregularities: a proposal for definition and classification. J Clin Aesthet Dermatol. 2024;17(4):24–27. - PMC - PubMed
    1. Pereira LH, Nicaretta B, Sterodimas A. Correction of liposuction sequelae by autologous fat transplantation. Aesthetic Plast Surg. 2011;35(6):1000–1008. - PubMed
    1. Toledo LS, Mauad R. Complications of body sculpture: prevention and treatment. Clin Plast Surg. 2006;33(1):1–11, v. - PubMed
    1. Castello MF, Lazzeri D, Agostini T et al. Management of contour irregularities following superficial liposuction. Plast Reconstr Surg. 2011;128(2):601–602. - PubMed
    1. Chang KN. Surgical correction of post-liposuction contour irregularities. Plast Reconstr Surg. 1994;94(1):26–136. - PubMed

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