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Review
. 2025 Feb 28;15(3):96.
doi: 10.3390/jpm15030096.

Precision Surgery for Glioblastomas

Stephen J Price  1 , Jasmine G Hughes  1 , Swati Jain  1   2 , Caroline Kelly  3 , Ioana Sederias  1 , Francesca M Cozzi  1 , Jawad Fares  1   4 , Yonghao Li  1 , Jasmine C Kennedy  1 , Roxanne Mayrand  1 , Queenie Hoi Wing Wong  1 , Yizhou Wan  1   5 , Chao Li  1   6
Affiliations
Review

Precision Surgery for Glioblastomas

Stephen J Price et al. J Pers Med. .

Abstract

Glioblastomas are the most common primary malignant brain tumor. Most of the recent improvements their treatment are due to improvements in surgery. Although many would consider surgery as the most personalized treatment, the variation in resection between surgeons suggests there remains a need for objective measures to determine the best surgical treatment for individualizing therapy for glioblastoma. We propose applying a personalized medicine approach to improve outcomes for patients. We suggest looking at personalizing preoperative preparation, improving the resection target by understanding what needs removing and what ca not be removed, and better patient selection with personalized rehabilitation plans for all patients.

Keywords: brain mapping; glioblastoma; prehabilitation; rehabilitation; surgical resection.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
Stages of a patient’s journey suitable for a personalized surgical approach. This is obtained, according to the multidisciplinary tumor board (MDT), through preoperative care, intraoperative management, and post-operative optimization for oncological therapies.
Figure 2
Figure 2
Summary of commonly available advanced MRI techniques and the pathological processes they can probe. (a) represents diffusion-weighted MRI, (b) is diffusion tensor, (c) is perfusion MRI and (d) is proton spectroscopy.
Figure 3
Figure 3
Examples of DTI tractography around a left temporal lobe glioblastoma. You can see the relationship of the tumor to the IFOF in yellow, the arcuate fasciculus (AF) in green, the corticospinal tract (CST) in red, and the ILF in blue.
See this image and copyright information in PMC

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