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. 2025 May;105(1):56-61.
doi: 10.1177/13872877251325878. Epub 2025 Mar 26.

Lifespan of male and female APP/PS1 and APPNL-F/NL-F mouse models of Alzheimer's disease

Hannah Roberts  1 , Yimin Fang  1 , Kathleen Quinn  1 , Tiarra Hill  1 , Mackenzie R Peck  1 , Andrzej Bartke  2   3 , Kevin N Hascup  1   3   4 , Erin R Hascup  1   4
Affiliations

Lifespan of male and female APP/PS1 and APPNL-F/NL-F mouse models of Alzheimer's disease

Hannah Roberts et al. J Alzheimers Dis. 2025 May.

Abstract

Alzheimer's disease (AD) disproportionately affects women, yet most preclinical research studies are male-centric. We performed lifespan analyses of male and female AD mouse models (APP/PS1 and APPNL-F/NL-F) and their shared genetic background control (C57BL/6). Survival curves support significant sex differences between genotypes. Minimal longevity revealed increased age in male APP/PS1, and decreased age in male APPNL-F/NL-F mice. Maximal longevity revealed an increased average age in males. Furthermore, median lifespan differed between sex and genotype. This study supports dimorphic survival in two mouse models of AD, emphasizing the need to examine mechanisms and treatments in both sexes.

Keywords: Alzheimer's disease; Kaplan-Meier estimate; amyloid-β; survival curve.

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Conflict of interest statement

Declaration of conflicting interestsThe author(s) declared the following potential conflicts of interest with respect to the research, authorship, and/or publication of this article: ER Hascup is an Editorial Board Member of this journal but was not involved in the peer-review process of this article nor had access to any information regarding its peer-review.The remaining authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

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