Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2025 Apr;51(4):793-795.
doi: 10.1007/s00134-025-07863-8. Epub 2025 Mar 26.

Rapid clinical effects of convalescent plasma therapy in severe COVID-19 acute respiratory distress syndrome (ARDS)

Karl Bihlmaier  1 , Carsten Willam  1 , Larissa Herbst  1 , Holger Hackstein #  2 , Mario Schiffer #  3 ; IPCO trial investigator group
Collaborators, Affiliations

Rapid clinical effects of convalescent plasma therapy in severe COVID-19 acute respiratory distress syndrome (ARDS)

Karl Bihlmaier et al. Intensive Care Med. 2025 Apr.
No abstract available

PubMed Disclaimer

Conflict of interest statement

Declarations. Conflicts of interest: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. This study was reviewed and approved by the ethics committee of the Friedrich-Alexander-University Erlangen (235-20 Az and 20-235_6-Az).

Figures

Fig. 1
Fig. 1
Effects of CP therapy on SOFA score and PaO2/FiO2 ratio. Panel A shows a box plot of daily SOFA scores in the CP + SOC compared to the SOC group. Rapid SOFA score improvement in the CP + SOC group gains high statistical significance within two days and is indicated by asterisks **p < 0.01, ***p < 0.001. Specific p-values for each day: day 2 p = 0.01652, day 3 p = 0.00059, day 4 p = 0.00049, day 5 p = 0.01002, day 6 p = 0.00008. Panel B shows a linear regression analysis of the SOFA score in the CP + SOC and SOC groups, respectively. SOFA scores were collected according to the trial protocol. Slope is − 0.16/day in the SOC + CP group and − 0.01/day in the SOC group. ***p < 0.001. Dotted lines indicate the 95% CI. Panel C indicates the fraction of patients with a PaO2/FiO2 ratio < 200 mmHg. CP therapy significantly improves oxygenation with a significant effect on day 3. *p < 0.05. Panel D demonstrates the effect of rescue CP therapy on PaO2/FiO2 ratio. Shown is a spaghetti plot of the PaO2/FiO2 ratios of all patients receiving rescue therapy (n = 14) in light grey. Timepoint of first rescue therapy administration is set to day 0. Linear regression analysis of PaO2/FiO2 ratios of both groups three days pre and post transfusion shows respiratory deterioration with a decline of − 3.2 mmHg/d of PaO2/FiO2 ratio before rescue therapy, and the therapeutic effect as a rise of PaO2/FiO2 ratio with + 12.7 mmHg/d post rescue therapy *p < 0.05
See this image and copyright information in PMC

References

    1. Klassen SA, Senefeld JW, Johnson PW, Carter RE, Wiggins CC, Shoham S, Grossman BJ, Henderson JP, Musser J, Salazar E, Hartman WR, Bouvier NM, Liu STH, Pirofski LA, Baker SE, van Helmond N, Wright RS, Fairweather D, Bruno KA, Wang Z, Paneth NS, Casadevall A, Joyner MJ (2021) The effect of convalescent plasma therapy on mortality among patients with COVID-19: systematic review and meta-analysis. Mayo Clin Proc 96:1262–1275 - PMC - PubMed
    1. Misset B, Piagnerelli M, Hoste E, Dardenne N, Grimaldi D, Michaux I, De Waele E, Dumoulin A, Jorens PG, van der Hauwaert E, Vallot F, Lamote S, Swinnen W, De Schryver N, Fraipont V, de Mey N, Dauby N, Layios N, Mesland JB, Meyfroidt G, Moutschen M, Compernolle V, Gothot A, Desmecht D, Pereira MITD, Garigliany M, Najdovski T, Bertrand A, Donneau AF, Laterre PF (2023) Convalescent plasma for COVID-19-induced ARDS in mechanically ventilated patients. New Engl J Med 389:1590 - PMC - PubMed
    1. Alhazzani W, Møller MH, Arabi YM, Loeb M, Gong MN, Fan E, Oczkowski S, Levy MM, Derde L, Dzierba A, Du B, Aboodi M, Wunsch H, Cecconi M, Koh Y, Chertow DS, Maitland K, Alshamsi F, Belley-Cote E, Greco M, Laundy M, Morgan JS, Kesecioglu J, McGeer A, Mermel L, Mammen MJ, Alexander PE, Arrington A, Centofanti JE, Citerio G, Baw B, Memish ZA, Hammond N, Hayden FG, Evans L, Rhodes A (2020) Surviving Sepsis Campaign: guidelines on the management of critically ill adults with Coronavirus Disease 2019 (COVID-19). Intensive Care Med 46:854–887 - PMC - PubMed
    1. Senefeld JW, Gorman EK, Johnson PW, Moir ME, Klassen SA, Carter RE, Paneth NS, Sullivan DJ, Morkeberg OH, Wright RS, Fairweather D, Bruno KA, Shoham S, Bloch EM, Focosi D, Henderson JP, Juskewitch JE, Pirofski LA, Grossman BJ, Tobian AAR, Franchini M, Ganesh R, Hurt RT, Kay NE, Parikh SA, Baker SE, Buchholtz ZA, Buras MR, Clayburn AJ, Dennis JJ, Diaz Soto JC, Herasevich V, Klompas AM, Kunze KL, Larson KF, Mills JR, Regimbal RJ, Ripoll JG, Sexton MA, Shepherd JRA, Stubbs JR, Theel ES, van Buskirk CM, van Helmond N, Vogt MNP, Whelan ER, Wiggins CC, Winters JL, Casadevall A, Joyner MJ (2023) Rates among hospitalized patients with COVID-19 treated with convalescent plasma: a systematic review and meta-analysis. Mayo Clin Proc Innov Qual Outcomes 7:499–513 - PMC - PubMed
    1. Joyner MJ, Carter RE, Senefeld JW, Klassen SA, Mills JR, Johnson PW, Theel ES, Wiggins CC, Bruno KA, Klompas AM, Lesser ER, Kunze KL, Sexton MA, Soto JCD, Baker SE, Shepherd JRA, van Helmond N, Verdun NC, Marks P, van Buskirk CM, Winters JL, Stubbs JR, Rea RF, Hodge DO, Herasevich V, Whelan ER, Clayburn AJ, Larson KF, Ripoll JG, Andersen KJ, Buras MR, Vogt MNP, Dennis JJ, Regimbal RJ, Bauer PR, Blair JE, Paneth NS, Fairweather DL, Wright RS, Casadevall A (2021) Convalescent plasma antibody levels and the risk of death from Covid-19. New Engl J Med 384:1015–1027 - PMC - PubMed

LinkOut - more resources