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Review
. 2025 Mar 18;26(6):2723.
doi: 10.3390/ijms26062723.

The Clinical Role of miRNAs in the Development and Treatment of Glioblastoma

Samantha Epistolio  1 , Paolo Spina  1 , Ismail Zaed  2 , Andrea Cardia  2 , Francesco Marchi  2 , Milo Frattini  1
Affiliations
Review

The Clinical Role of miRNAs in the Development and Treatment of Glioblastoma

Samantha Epistolio et al. Int J Mol Sci. .

Abstract

Glioblastoma multiforme (GBM) is the most common brain tumor and one of the most aggressive, with a median overall survival (OS) of only 15-18 months. These characteristics make it necessary to identify new targets for the improvement of prognosis and better prediction of response to therapies currently available for GBM patients. One possible candidate target could be the evaluation of miRNAs. miRNAs are small non-coding RNAs that play important roles in post-transcriptional gene regulation. Due to their functions, miRNAs also control biological processes underlying the development of GBM and may be considered possible targets with a clinical role. This narrative review introduces the concept of miRNAs in GBM from a clinical and a molecular perspective and then addresses the specific miRNAs that are most described in the literature as relevant for the development, the prognosis, and the response to therapies for patients affected by GBM.

Keywords: GBM; TMZ; miRNAs; prognosis; survival; treatment.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
Pathway of miRNA biogenesis and action. For a specific description of the pathway, please refer to the text of the review. The figure was created by applying images reported at https://smart.servier.com/.
Figure 2
Figure 2
Targets of oncomiR in glioblastoma. miRNAs that block a specific pathway are shown in red, and those that activate a pathway are in green. For a specific description of the pathways reported in this figure, please refer to the text of the review. The figure was created applying images reported at https://smart.servier.com/.
Figure 3
Figure 3
Targets of tumor-suppressor miRNAs in glioblastoma. miRNAs that block a specific pathway are shown in red, and those that activate a pathway are in green. For a specific description of the pathways reported in this figure, please refer to the text of the review. The figure was created by applying images reported at https://smart.servier.com/.
See this image and copyright information in PMC

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