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Review
. 2025 Mar 16;30(6):1335.
doi: 10.3390/molecules30061335.

Flaxseed in Diet: A Comprehensive Look at Pros and Cons

Sara Duarte  1 , Muhammad Ajmal Shah  2 , Ana Sanches Silva  1   3   4
Affiliations
Review

Flaxseed in Diet: A Comprehensive Look at Pros and Cons

Sara Duarte et al. Molecules. .

Abstract

Flaxseeds, which have been consumed for thousands of years, have recently gained increasing popularity due to their rich composition, including omega-3 fatty acids, lignans, proteins, and fibers. These components are strongly associated with various health benefits, such as improving cardiovascular health, preventing certain types of cancer, controlling diabetes, promoting gastro-intestinal well-being, and aiding in weight management. This monograph explores the role of flaxseeds in nutrition, as well as their potential risks. Despite their numerous health benefits, flaxseeds also represent concerns due to excessive consumption and possible contamination, particularly from cyanogenic glycosides. Therefore, the levels of these compounds must be controlled, and this monograph also analyzes the available methods to detect and reduce these contaminants, ensuring the safety of flaxseed and flaxseed products consumers. Flaxseed is considered a valuable addition when incorporated into the diet, but it is necessary to continue research and promote technological improvements to maximize their benefits and minimize their risks.

Keywords: benefits; cyanogenic glycosides; determination methods; detoxification methods; diet; flaxseed.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
(a) Whole golden flaxseed; (b) milled golden flaxseed.
Figure 2
Figure 2
Diverse health benefits associated with incorporating flaxseed into the diet. c-erB2: human epidermal growth factor receptor 2; HbA1c: glycated hemoglobin; HOMA-IR: homeostasis model assessment-estimated insulin resistance; Ki-67: antigen kiel 67; QUICKI: quantitative insulin sensitivity check index; TC: total cholesterol.
Figure 3
Figure 3
Detoxification methods to reduce the content of flaxseeds in cyanogenic glycosides. UAD: ultrasound-assisted detoxification.
See this image and copyright information in PMC

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