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Review
. 2025 Mar 13;13(3):652.
doi: 10.3390/microorganisms13030652.

Candida auris: A Continuing Threat

Ashish Bhargava  1   2 , Katherine Klamer  1 , Mamta Sharma  1 , Daniel Ortiz  3 , Louis Saravolatz  1   2
Affiliations
Review

Candida auris: A Continuing Threat

Ashish Bhargava et al. Microorganisms. .

Abstract

Candida auris is a World Health Organization critical-priority fungal pathogen that has variable resistance to antifungal treatments. Multiple clades have been identified through genomic analysis and have appeared in different geographic locations simultaneously. Due to a combination of factors including antifungal resistance, ability to colonize and persist in the environment, and thermotolerance, it can thrive. Infected patients are associated with a high mortality rate, especially those with multiple health risk factors like those associated with other Candida species. This review highlights the current situation of this pathogen to help provide guidance for future work.

Keywords: Candida auris; antifungal resistance; nosocomial transmission; pathogenic fungi.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
Candida auris virulence factors. ALS—agglutin-like sequence, GPI—glycosylphosphatidylinositol, MIC—minimum inhibitory concentration, NET—neutrophil extracellular traps, Hog—high osmolarity glycerol, SAPK—stress-activated protein kinase, SAP—secreted aspartyl proteases.
Figure 2
Figure 2
Common misidentifications for Candida auris on biochemical systems [88,89]. Vitek (BioMerieux, Craponne, France), BD Phoenix (BD Biosciences, NJ, USA), API 20C (BioMerieux, France), Microscan (Beckman Coulter, CA, USA, RapiID Yeast Plus (Remel, KS, USA).
See this image and copyright information in PMC

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