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. 2026 Mar 1;21(3):1104-1105.
doi: 10.4103/NRR.NRR-D-24-01465. Epub 2025 Mar 25.

Lysophosphatidic acid signaling: Transmembrane modulators in the central nervous system

Alexandra Polyzou  1 , Alexandros K Tsiouris  1 , Charalampos Labrakakis  2   3 , Britta J Eickholt  4 , George Leondaritis  1   3
Affiliations

Lysophosphatidic acid signaling: Transmembrane modulators in the central nervous system

Alexandra Polyzou et al. Neural Regen Res. .
No abstract available

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Figures

Figure 1
Figure 1
Summary of regulators and effectors of LPA in the developing and adult central nervous system. (A) LPA species, abundance, and chaperones. (B–D) LPA synthesis and dephosphorylation. (E) Concentration range of LPA regulator/effector activities. (F–H) Plasma membrane LPA effectors including typical LPARs/GPCRs and atypical 6-TM membrane proteins. Values in panel E correspond to either Km values for enzymes ATX and PLPP1, or Kd values for LPARs, or EC50 values for functional assays (where applicable). For TRPs and PLPPRs the values are indicative based on functional assays (see text for details). CSF LPA levels are from Crack et al. (2014). Structures in B–D and F–H: ATX gamma in complex with LPA 18:1 (PDB ID: 8C3P); PLPP1 (AlphaFold, AF-O14494-F1); mPA-PLA1a/LIPH (AlphaFold, AF-Q8WWY8-F1); LPAR1 bound to LPA and Gi (PDB ID: 7TD0); ΤRPV1 full-length tetramer structure (PDB ID: 7LP9); PLPPR1 (AlphaFold, AF-Q8TBJ4-F1). CSF: Cerebrospinal fluid; LPA: lysophosphatidic acid; LPC: lysophosphatidylcholine; MAG: monoacylglycerol; PA: phosphatidic acid; T1/2: half-time; TM: transmembrane region.
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