Chronic Cough and Pulmonary Manifestations of Laryngopharyngeal Reflux Disease

Abstract

Laryngopharyngeal reflux plays an important role in respiratory diseases such as chronic cough, asthma, chronic obstructive pulmonary disease, interstitial lung disease, and lung transplantation, among others. In cases of refractory chronic cough, reflux testing (hypopharyngeal-esophageal multichannel intraluminal impedance with dual-PH sensor and high-resolution esophageal manometry) will assist the clinician in determining whether additional reflux treatment steps should be undertaken. It is important to consider all mechanisms of reflux pathophysiology to yield the optimal result in the management of a patient with chronic respiratory disease.

Keywords: Chronic cough; Gastroesophageal reflux disease; Laryngopharyngeal reflux; Pulmonary; Refractory chronic cough; Respiratory.