Promoting equitable patient representation in therapeutic clinical trials by accounting for population disease burden

Affiliations

¹ Harvard Medical School, Boston, MA, USA.
² Department of Radiation Oncology, Stanford Health Care, Palo Alto, CA, USA. ktaparra@stanford.edu.
³ Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
⁴ Department of Epidemiology & Biostatistics, University of California, San Francisco, CA, USA.

Comment

Megan Y Gimmen et al. Sci Rep. 2025.

. 2025 Mar 27;15(1):10591.

doi: 10.1038/s41598-025-91174-x.

¹ Harvard Medical School, Boston, MA, USA.
² Department of Radiation Oncology, Stanford Health Care, Palo Alto, CA, USA. ktaparra@stanford.edu.
³ Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
⁴ Department of Epidemiology & Biostatistics, University of California, San Francisco, CA, USA.

No abstract available

Conflict of interest statement

Declarations. Competing interests: The authors report no competing interests.

Demographic recruitment bias of adults in United States randomized clinical trials by disease categories between 2008 to 2019: a systematic review and meta-analysis.
Buffenstein I, Kaneakua B, Taylor E, Matsunaga M, Choi SY, Carrazana E, Viereck J, Liow KK, Ghaffari-Rafi A. Buffenstein I, et al. Sci Rep. 2023 Jan 2;13(1):42. doi: 10.1038/s41598-022-23664-1. Sci Rep. 2023. PMID: 36593228 Free PMC article.

1. Buffenstein, I. et al. Demographic recruitment bias of adults in United States randomized clinical trials by disease categories between 2008 to 2019: A systematic review and meta-analysis. Sci. Rep.13, 42 (2023). - PMC - PubMed
1. Revisions to the Standards for the Classification of Federal Data on Race and Ethnicity. Federal Register. https://www.federalregister.gov/documents/2016/09/30/2016-23672/standard... (2016).
1. Taparra, K. Pacific islanders searching for inclusion in medicine. JAMA Health Forum2, e210153 (2021). - PubMed
1. Strait, A. et al. Demographic characteristics of participants in rheumatoid arthritis randomized clinical trials: A systematic review. JAMA Netw. Open2, e1914745 (2019). - PMC - PubMed
1. Duma, N. et al. Representation of minorities and women in oncology clinical trials: Review of the past 14 years. J. Oncol. Pract.14, e1–e10 (2018). - PubMed