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Review
. 2025 Mar 7;13(3):656.
doi: 10.3390/biomedicines13030656.

Neurogenic Inflammation in Allergic Contact Dermatitis

Ernesto Aitella  1 , Massimo De Martinis  1 , Ciro Romano  2 , Gianluca Azzellino  1 , Lia Ginaldi  1
Affiliations
Review

Neurogenic Inflammation in Allergic Contact Dermatitis

Ernesto Aitella et al. Biomedicines. .

Abstract

Allergic contact dermatitis (ACD) is a skin condition characterized by inflammation resulting from hypersensitivity upon contact with certain allergens. Although ACD is characterized by an immune-mediated pathomechanism, the involvement of the nervous system in this condition has increasingly been considered, particularly in the amplification and persistence of inflammation. This paper aims to present a comprehensive overview of the mechanisms involved in neurogenic inflammation in ACD, focusing on the role of sensory neurons, the release of neuropeptides, their interaction with immune cells, and the potential therapeutic implications related to neurogenic pathways, diversified by age and gender. Innovative therapies for ACD, including topical formulations, may target the mass-bound X2 G-protein-coupled receptor (MRGPRX2) and endocannabinoid systems.

Keywords: MRGPRX2; allergic contact dermatitis; endocannabinoid system; mast cell; neurogenic inflammation; substance P.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
Neurogenic contribution to allergic contact dermatitis.
See this image and copyright information in PMC

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