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. 2025 Apr;45(2):430-436.
doi: 10.19852/j.cnki.jtcm.2025.02.021.

Efficacy and safety of Qingwei Zhitong pellets-containing quadruple therapy for eradication: a prospective, single-center, randomized trial

Cheng Jianping  1 , Fan Chanjuan  1 , Zhai Lili  1 , Wang Hui  1 , Xie Dongling  1 , Cai Yong  1 , L I Zhen  1 , Huang Kun  1 , Bai Qixuan  1
Affiliations

Efficacy and safety of Qingwei Zhitong pellets-containing quadruple therapy for eradication: a prospective, single-center, randomized trial

Cheng Jianping et al. J Tradit Chin Med. 2025 Apr.

Abstract

Objective: To evaluate the efficacy and safety of 14-day Qingwei Zhitong pellets (, QZ)-containing quadruple therapy (QZQT) compared to bismuth-containing quadruple therapy (BQT) in treatment-naive patients with Helicobacter pylori (H. pylori) infection.

Methods: This single-center, randomized controlled clinical trial enrolled 333 patients, who were divided into either the QZQT group (QZ pellets, 3.2 g, three times daily; rabeprazole, 10 mg, twice daily; amoxicillin 1000 mg, twice daily; clarithromycin, 500 mg, twice daily) or the BQT group (bismuth potassium citrate, 1000 mg, three times daily; rabeprazole, 10 mg, twice daily; amoxicillin, 1000 mg, twice daily; clarithromycin, 500 mg, twice daily) for 14 d. The 13C-urea breath test assessed eradication success at least four weeks after treatment. The primary outcome focused on the eradication rate, with secondary outcomes including safety and patient compliance.

Results: From August 2022 to June 2023, 342 subjects were screened, and 333 were randomized. The QZQT and BQT groups showed eradication rates of 68.9% and 67.8% (P = 0.838) by intention-to-treat (ITT) analysis, respectively, and 71.1% and 68.3% (P = 0.612) by per-protocol (PP) analysis, respectively. QZQT was non-inferior to BQT in both ITT and PP analyses. QZQT was associated with fewer side effects (57.8% of patients) than BQT (90.4%) (P < 0.001).

Conclusion: The 14 d QZQT treatment demonstrates equal efficacy in eradicating H. pylori infection and improved patient compliance and safety compared to BQT. These results provide evidence supporting 14-day QZQT as an acceptable treatment for H. pyloriinfection.

Keywords: Qingwei Zhitong pellets; bismuth; eradication; quadruple therapy; randomized controlled trial.

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Figures

Figure 1
Figure 1. Flow chart of patient enrolment and study design
ITT: intention-to-treat; PP: per-protocol; QZQT: Qingwei Zhitong pellets-containing quadruple therapy; BQT: bismuth-containing quadruple therapy.
See this image and copyright information in PMC

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