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Observational Study
. 2025 May;29(5):e70013.
doi: 10.1002/ejp.70013.

Prevalence of Painful Temporomandibular Disorders and Overlapping Primary Headaches Among Young Adults

Affiliations
Observational Study

Prevalence of Painful Temporomandibular Disorders and Overlapping Primary Headaches Among Young Adults

Cristina Rocha Exposto et al. Eur J Pain. 2025 May.

Abstract

Background: Large population-based estimates of the prevalence of painful temporomandibular disorders (p-TMD) utilising standardised screening tools are scarce and have not investigated the prevalence of overlapping primary headaches. We aimed to estimate the prevalence of p-TMD in a large population of young adults (18 to 23 years) and to estimate the co-occurrence of p-TMD and two primary headaches, migraine and tension-type headache (TTH). The study also aimed to examine the extent of psychological (PHQ-4) and physical (PHQ-15) comorbidities and report prevalence across three gender categories (women, men and other).

Methods: Survey data from the Danish National Birth Cohort were collected (n = 11,982), in a cross-sectional observational design. A sensitivity analysis was conducted to address participation bias, revealing minimal impact on the estimates.

Results: The overall prevalence of p-TMD was 26.4% with gender-specific prevalence of women: 31.5%, other: 39.2% and men: 16.8%. Among those with p-TMD, 80.5% reported headaches at least once a month, and 13.8% over 15 days monthly. For the p-TMD individuals with a medical headache diagnosis, 31.9% experienced TTH and 10.9% migraine. The study also identified a higher proportion of moderate/severe psychological distress and physical symptoms in the p-TMD group compared to the non-p-TMD group. Logistic regression revealed a positive association between PHQ-4 and p-TMD, modified by gender (p = 0.016).

Conclusions: High overall prevalence of p-TMD and overlapping primary headaches was found in young adults. In addition, the study reports gender-specific associations between p-TMD, psychological distress and physical comorbidities indicating that this association is stronger for men than for women.

Significance statement: This study found a higher-than-expected prevalence of painful temporomandibular disorders in young adults. It is based on a large population cohort and used standardised and validated screening tools. The study also reported common co-occurrence of primary headaches and explored gender differences. The study raises awareness for a possibly underestimated health burden in young individuals, particularly among individuals experiencing psychological distress and multiple physical symptoms.

Keywords: cohort studies; dentistry; facial pain; gender diversity; headaches; population health; temporomandibular disorders.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

FIGURE 1
FIGURE 1
Prevalence and response rate. This table presents response rates, prevalence of positive and negative screening for painful temporomandibular disorders (p‐TMD), prevalence of headaches categorised as < 1 or ≥ 1 days per month, and gender distribution (Women, Men and Other). Prevalence was calculated as the proportion of participants who completed the TMD pain screener (n = 11,982) and reported headache frequency (n = 11,803). 95% confidence intervals are provided. ‘p‐TMD’ denotes painful temporomandibular disorders, while ‘W’ and ‘M’ represent Women and Men, respectively. ‘n’ indicates the number of individuals, and ‘%’ signifies the proportion relative to the total number of participants completing both. *Specific data for genders with fewer than 5 individuals are not disclosed to safeguard privacy and confidentiality.

References

    1. Ballegaard, V. , Thede‐Schmidt‐Hansen P., Svensson P., and Jensen R.. 2008. “Are Headache and Temporomandibular Disorders Related? A Blinded Study.” Cephalalgia 28, no. 8: 832–841. 10.1111/j.1468-2982.2008.01597.x. - DOI - PubMed
    1. Bevilaqua‐Grossi, D. , Lipton R. B., Napchan U., Grosberg B., Ashina S., and Bigal M. E.. 2010. “Temporomandibular Disorders and Cutaneous Allodynia Are Associated in Individuals With Migraine.” Cephalalgia 30: 425–432. - PubMed
    1. Bjerregaard, A. A. , Halldorsson T. I., Tetens I., and Olsen S. F.. 2019. “Mother's Dietary Quality During Pregnancy and Offspring's Dietary Quality in Adolescence: Follow‐Up From a National Birth Cohort Study of 19,582 Mother‐Offspring Pairs.” PLoS Medicine 16, no. 9: e1002911. 10.1371/journal.pmed.1002911. - DOI - PMC - PubMed
    1. Borgogna, N. C. , McDermott R. C., Aita S. L., and Kridel M. M.. 2019. “Anxiety and Depression Across Gender and Sexual Minorities: Implications for Transgender, Gender Nonconforming, Pansexual, Demisexual, Asexual, Queer, and Questioning Individuals.” Psychology of Sexual Orientation and Gender Diversity 6, no. 1: 54–63. 10.1037/sgd0000306. - DOI
    1. Dahlström, L. , and Carlsson G. E.. 2010. “Temporomandibular Disorders and Oral Health‐Related Quality of Life. A Systematic Review.” Acta Odontologica Scandinavica 68, no. 2: 80–85. 10.3109/00016350903431118. - DOI - PubMed

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