Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Editorial
. 2025 Aug;73(2):161-162.
doi: 10.1165/rcmb.2024-0564ED.

Senescence at the Crossroads of Lung Development and Injury

Kent A Willis  1 , Namasivayam Ambalavanan  1
Affiliations
Editorial

Senescence at the Crossroads of Lung Development and Injury

Kent A Willis et al. Am J Respir Cell Mol Biol. 2025 Aug.
No abstract available

PubMed Disclaimer

Comment on

  • Elevated Senescence Markers in Developing Trisomy 21 Human Lungs.
    Belgacemi R, Cherry C, Thompson M, Koloko Ngassie M, Rehan A, El Alam I, Jourdan Le Saux C, Glass I, Britt RD Jr, Prakash YS, Pabelick C, Danopoulos S, Al Alam D. Belgacemi R, et al. Am J Respir Cell Mol Biol. 2025 Aug;73(2):251-263. doi: 10.1165/rcmb.2024-0361OC. Am J Respir Cell Mol Biol. 2025. PMID: 40019852

References

    1. McHugh D, Durán I, Gil J. Senescence as a therapeutic target in cancer and age-related diseases. Nat Rev Drug Discov . 2025;24:57–71. - PubMed
    1. Parikh P, Wicher S, Khandalavala K, Pabelick CM, Britt RD, Prakash YS. Cellular senescence in the lung across the age spectrum. Am J Physiol Lung Cell Mol Physiol . 2019;316:L826–L842. - PMC - PubMed
    1. Hayflick L, Moorhead PS. The serial cultivation of human diploid cell strains. Exp Cell Res . 1961;25:585–621. - PubMed
    1. Álvarez D, Cárdenes N, Sellarés J, Bueno M, Corey C, Hanumanthu VS, et al. IPF lung fibroblasts have a senescent phenotype. Am J Physiol Lung Cell Mol Physiol . 2017;313:L1164–L1173. - PMC - PubMed
    1. Woldhuis RR, Heijink IH, van den Berge M, Timens W, Oliver BGG, de VM, et al. COPD-derived fibroblasts secrete higher levels of senescence-associated secretory phenotype proteins. Thorax . 2021;76:508–511. - PMC - PubMed

LinkOut - more resources