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. 2025 Mar;30(12):2500174.
doi: 10.2807/1560-7917.ES.2025.30.12.2500174.

Enhanced influenza vaccines impact effectiveness in individuals aged 65 years and older, Denmark, 2024/25 influenza season up to 4 March 2025

Hanne-Dorthe Emborg  1 , Palle Valentiner-Branth  1 , Ramona Trebbien  2 , Amanda Bolt Botnen  2 , Tyra Grove Krause  3 , Bolette Søborg  1
Affiliations

Enhanced influenza vaccines impact effectiveness in individuals aged 65 years and older, Denmark, 2024/25 influenza season up to 4 March 2025

Hanne-Dorthe Emborg et al. Euro Surveill. 2025 Mar.

Abstract

During the 2024/25 influenza season, enhanced and standard-dose influenza vaccines were available for individuals aged 65 and older. Compared with the standard-dose quadrivalent influenza vaccine (QIV), the adjuvanted QIV was significantly more effective, with an overall vaccine effectiveness (VE) of 48% (95% CI: 42-52) vs 33% (95% CI: 24-41) when considering both non-hospitalised and hospitalised patients. The high-dose QIV demonstrated similar effectiveness to the adjuvanted QIV. These findings support the inclusion of enhanced influenza vaccines in future vaccination programmes.

Keywords: Influenza; type specific; vaccine effectiveness; ≥ 65 years.

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Conflict of interest statement

Conflict of interest: None declared.

Figures

Figure 1
Figure 1
Distribution of vaccine types by age in people aged 65 and older vaccinated against influenza, Denmark, 1 October–31 December 2024 (n = 20,615)
Figure 2
Figure 2
Proportion of influenza A subtypes by 5-year age groups, Denmark, 2024/25 season up to 4 March 2025 (n = 319)
See this image and copyright information in PMC

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