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Review
. 2025 May 2:220:115369.
doi: 10.1016/j.ejca.2025.115369. Epub 2025 Mar 22.

Primary mediastinal B-cell lymphoma (PMBCL): The LYSA pragmatic guidelines

Loïc Renaud  1 , Marie Donzel  2 , Justine Decroocq  3 , Pierre Decazes  4 , Jean Galtier  5 , Barbara Burroni  6 , Elena-Liana Veresezan  7 , Côme Sesboüé  8 , Peggy Dartigues  9 , Catherine Chassagne-Clément  10 , Laurent Martin  11 , Claire Mauduit  12 , Sophie Kaltenbach  13 , Dominique Penther  14 , Pascaline Etancelin  14 , David Sibon  15 , Sarah Bailly  16 , Valentine Martin  17 , Eric Durot  18 , Youlia Kirova  19 , Adrien Grenier  20 , Marie Maerevoet  21 , Wivine Bernard  22 , Louise Naveau  23 , Aurélie Cabannes-Hamy  24 , Anne-Ségolène Cottereau  25 , Nicolas Jacquet-Francillon  26 , Robin Noel  27 , Thibaut Reichert  28 , Clémentine Sarkozy  29 , Lucile Bussot  30 , Sébastien Bailly  31 , Sandy Amorim  32 , Daphné Krzisch  20 , Jérôme Cornillon  33 , Hugo Legendre  34 , Florian Chevillon  35 , Doriane Cavalieri  36 , Pierre Sesques  37 , Véronique Minard-Colin  38 , Corinne Haioun  15 , Franck Morschhauser  36 , Roch Houot  39 , Fabrice Jardin  40 , Hervé Tilly  40 , Alexandra Traverse-Glehen  2 , Vincent Camus  41
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Free article
Review

Primary mediastinal B-cell lymphoma (PMBCL): The LYSA pragmatic guidelines

Loïc Renaud et al. Eur J Cancer. .
Free article

Abstract

Primary mediastinal B-cell lymphoma (PMBCL) is a distinct subtype of large B-cell lymphoma with unique clinical, histopathological, and molecular characteristics. Despite its aggressive nature, PMBCL has a high cure rate when managed appropriately. Advances in the understanding of PMBCL biological characteristics, coupled with improvements in diagnostic tools and therapeutic approaches, have significantly improved patient outcomes in recent years. In this article, we present a set of pragmatic guidelines developed by the Lymphoma Study Association (LYSA) for the management of PMBCL. These guidelines address key aspects of diagnosis, staging, response evaluation, and treatment, integrating the latest evidence from clinical trials, expert consensus, and real-world practice. The aim of the guidelines is to provide clinicians with a clear, practical framework to optimize care for patients with PMBCL, ensuring that the best available evidence is translated into clinical practice.

Keywords: Guidelines; LYSA; Primary mediastinal B-cell lymphoma.

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Conflict of interest statement

Declaration of Competing Interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: LR has received honoraria from Janssen, Takeda, BMS and AbbVie. VC has received honoraria from Incyte, AbbVie, Astra Zeneca, BMS, Ideogen, Janssen, Kiowa Kirin, Kite/Gilead, Lilly, Novartis, Octapharma, Secura Bio, Pfizer, Sanofi, and Takeda. JG has received honoraria from Kite/Gilead and Takeda. All the remaining authors declare that they have no conflicts of interest.

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