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Editorial
. 2025 Jun:81:104461.
doi: 10.1016/j.breast.2025.104461. Epub 2025 Mar 24.

Towards precision therapy in HER2-positive early-stage breast cancer

Affiliations
Editorial

Towards precision therapy in HER2-positive early-stage breast cancer

Serena Di Cosimo et al. Breast. 2025 Jun.
No abstract available

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Conflict of interest statement

Declaration of competing interest The authors declare the following financial interests/personal relationships that may be considered potential competing interests: Serena Di Cosimo reported receiving an institutional grant (IG 20774) from the Fondazione Associazione Italiana per la Ricerca sul Cancro (AIRC); funding from the Cancer Can.Heal European EU4Health Programme (101080009 - European Commission); serving as an “ad hoc” medical monitor for Medica Scientia Innovation Research (MEDSIR), Barcelona (Spain); as well as support for attending meetings and/or travel from Daiichi Sankyo, and participation in an advisory board for Pfizer. Paolo Verderio and Serena Di Cosimo are leading the PNRR-POC-2023-12378113 project, founded by the European Union - Next Generation EU – PNRR M6C2 – Investimento 2.1 Valorizzazione e potenziamento della ricerca biomedical del SSN, titled “A Composite Assay for HER2-Positive Early-Stage Breast Cancer Management”.

References

    1. Early Breast Cancer Trialists’ Collaborative group (EBCTCG) Trastuzumab for early-stage,HER2-positive breast cancer: a meta-analysis of 13 864 women in seven randomised trials. Lancet Oncol. 2021;22(8):1139–1150. doi: 10.1016/S1470-2045(21)00288-6. - DOI - PMC - PubMed
    1. Harbeck N. Neoadjuvant and adjuvant treatment of patients with HER2-positive early breast cancer. Breast. 2022;62(Suppl 1):S12–S16. doi: 10.1016/j.breast.2022.01.006. - DOI - PMC - PubMed
    1. Prat A., Guarneri V., Paré L., et al. A multivariable prognostic score to guide systemic therapy in early-stage HER2-positive breast cancer: a retrospective study with an external evaluation. Lancet Oncol. 2020;21(11):1455–1464. doi: 10.1016/S1470-2045(20)30450-2. - DOI - PMC - PubMed
    1. Prat A., Guarneri V., Pascual T., et al. Development and validation of the new HER2DX assay for predicting pathological response and survival outcome in early-stage HER2-positive breast cancer. EBioMedicine. 2022;75 doi: 10.1016/j.ebiom.2021.103801. - DOI - PMC - PubMed
    1. Verderio P., Mangia A., Ciniselli C.M., Tagliabue P., Paradiso A. Biomarkers for early cancer detection - methodological aspects. Breast Care. 2010;5:62–65. doi: 10.1159/000303956. - DOI - PMC - PubMed

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