The FBP1-TP53-NRF2 metabolic switch in metabolic dysfunction-associated steatohepatitis-hepatocellular carcinoma progression and senescence reversal

Yahui Zhu¹, Donglin Wei¹, Michael Karin², Li Gu^{3

4}

Affiliations

¹ School of Medicine, Chongqing University, Chongqing, China.
² Departments of Pharmacology and Pathology, Laboratory of Gene Regulation and Signal Transduction, School of Medicine, University of California San Diego (UCSD), La Jolla, California, USA.
³ Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, China.
⁴ Clinical Laboratory Medicine Research Center, West China Hospital, Sichuan University, Chengdu, China.

Yahui Zhu et al. Clin Transl Med. 2025 Apr.

. 2025 Apr;15(4):e70293.

doi: 10.1002/ctm2.70293.

Yahui Zhu¹, Donglin Wei¹, Michael Karin², Li Gu^{3

4}

¹ School of Medicine, Chongqing University, Chongqing, China.
² Departments of Pharmacology and Pathology, Laboratory of Gene Regulation and Signal Transduction, School of Medicine, University of California San Diego (UCSD), La Jolla, California, USA.
³ Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, China.
⁴ Clinical Laboratory Medicine Research Center, West China Hospital, Sichuan University, Chengdu, China.

No abstract available

Conflict of interest statement

The authors declare no conflict of interest.

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