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Review
. 2025 Mar 4:10:116-128.
doi: 10.1016/j.cnp.2025.02.008. eCollection 2025.

Prognostic models for seizures and epilepsy after stroke, tumors and traumatic brain injury

Kai Michael Schubert  1 , Anton Schmick  1 , Miranda Stattmann  1 , Marian Galovic  1
Affiliations
Review

Prognostic models for seizures and epilepsy after stroke, tumors and traumatic brain injury

Kai Michael Schubert et al. Clin Neurophysiol Pract. .

Abstract

Epilepsy is a frequent consequence of acute brain injuries, such as stroke, brain tumors, and traumatic brain injury (TBI). Accurate prediction of epilepsy is essential for early intervention and improved patient outcomes. This review evaluates the best-established prognostic models, including the SeLECT and CAVE scores, which estimate the risk of developing seizures and epilepsy following these injuries. The review highlights their clinical applicability, predictive accuracy, and limitations for different etiologies. In addition to providing practical tables for risk estimation, we also offer user-friendly online calculators for these models at www.predictepilepsy.com to facilitate clinical implementation. These tools help identify high-risk patients and support decision-making for follow-up and treatment. Furthermore, we discuss the potential of integrating electrophysiological data, including EEG biomarkers, to further enhance prediction accuracy and patient care. These insights highlight the need for further refinement and validation of predictive models, enabling more personalized treatment strategies and better patient care.

Keywords: Brain tumor-related epilepsy; Post-stroke epilepsy; Post-traumatic epilepsy; Prognostic model; Wpilepsy.

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Figures

Fig. 1
Fig. 1
Workflow for Developing, Validating, and Translating Prognostic Models into Practical Clinical Tools.
Fig. 2
Fig. 2
Prognostic models for selzures and epilepsy stroke, tumours and traumatic brain injury.
See this image and copyright information in PMC

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