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. 2025 Mar 14:16:1547627.
doi: 10.3389/fneur.2025.1547627. eCollection 2025.

Association between triglyceride-glucose index and the risk of stroke among moyamoya patients: a single-center retrospective study

Chi Zhang #  1 , Kai Guo #  1 , Hong Xu  1 , Gang Kong  1 , Chuanghong Liu  1
Affiliations

Association between triglyceride-glucose index and the risk of stroke among moyamoya patients: a single-center retrospective study

Chi Zhang et al. Front Neurol. .

Abstract

Background: Moyamoya disease increases the risk of strokes by impairing cerebral circulation, significantly affecting patients' quality of life. Despite the profound implications of this condition, there is a limited body of research exploring the factors that contribute to strokes in patients with Moyamoya disease. This study aims to evaluate the predictive value of the triglyceride-glucose index (TyG index) in forecasting stroke events among individuals diagnosed with moyamoya disease.

Methods: A total of 84 patients diagnosed with Moyamoya disease were treated at Changshu First People's Hospital from 01 January 2019 to 31 October 2024 were included in this study. We systematically collected and analyzed their clinical histories, laboratory test results, and baseline data. The patients were classified into two groups based on their history of cerebral stroke. Subsequently, we conducted a comparison and analysis of the TyG index between these two groups.

Results: The TyG index observed in patients with moyamoya disease who have a history of cerebral stroke was significantly elevated compared to that of patients without such a history. This difference was found to be statistically significant (p < 0.05). Furthermore, regression cubic splines analysis indicated a noteworthy linear relationship between the TyG index and the occurrence of cerebral stroke events.

Conclusion: In individuals diagnosed with Moyamoya disease, the TyG index has been shown to have a significant correlation with the risk of cerebral stroke. Furthermore, it has the potential to serve as an effective predictor for the occurrence of stroke.

Keywords: Moyamoya disease; atherosclerosis of the arteries; insulin resistance; stroke; triglyceride-glucose index.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Receiver operating characteristic (ROC) curve analysis of the TyG index for predicting stroke in patients with Moyamoya disease.
Figure 2
Figure 2
Radar cross section (RCS) statistical curve.
Figure 3
Figure 3
Subgroup analyses.
See this image and copyright information in PMC

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