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Case Reports
. 2025 Jun;44(6):1523-1526.
doi: 10.1007/s10096-025-05117-5. Epub 2025 Mar 31.

Salvage therapy of complicated Candida albicans spondylodiscitis with Rezafungin

Nina Grasselli Kmet  1   2 , Roberto Luzzati  3 , Jacopo Monticelli  4 , Stella Babich  4 , Jacopo Conti  5 , Stefano Di Bella  3
Affiliations
Case Reports

Salvage therapy of complicated Candida albicans spondylodiscitis with Rezafungin

Nina Grasselli Kmet et al. Eur J Clin Microbiol Infect Dis. 2025 Jun.

Abstract

Invasive fungal infections, particularly those caused by Candida species, represent an increasing cause of hospital-related morbidity and mortality. Most commonly Candida spp. is the causative agent of candidemia and invasive candidiasis. In this report we present a complex case of Candida albicans spondylodiscitis, successfully treated with rezafungin, a new echinocandin suitable for weekly outpatient administration. This case illustrates the first documented use of rezafungin in an outpatient setting for C. albicans spondylodiscitis, demonstrating its potential in managing complex fungal infections.

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Conflict of interest statement

Declarations. Ethics approval and consent to participate: The patient’s written consent was obtained. The authors affirm that human research participants provided informed consent for publication of the images in Fig. 2. Competing interests: The authors declare no competing interests.

References

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