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Case Reports
. 2025 Jun 5;145(23):2788-2793.
doi: 10.1182/blood.2024028172.

Cyclophosphamide mitigates non-ICANS neurotoxicities following ciltacabtagene autoleucel treatment

Viktoria Blumenberg  1 , Benjamin R Puliafito  1   2 , Charlotte E Graham  3 , Mark B Leick  1   2 , Md Raihan Chowdhury  1 , Maxx King  1 , Deshea L Harris  1 , Noopur S Raje  1   2 , Andrew R Branagan  1   2 , Andrew J Yee  1   2 , Diana Cirstea  1   2 , Kathleen M E Gallagher  1 , Jörg Dietrich  1   4 , Marcela V Maus  1   2 , Matthew J Frigault  1   2
Affiliations
Case Reports

Cyclophosphamide mitigates non-ICANS neurotoxicities following ciltacabtagene autoleucel treatment

Viktoria Blumenberg et al. Blood. .

Abstract

Potentially fatal non-immune effector cell-associated neurotoxicity syndrome neurotoxicities (NINTs) after B-cell maturation antigen-targeted chimeric antigen receptor (CAR) T-cell therapy have been linked to high CAR T-cell expansion. Cyclophosphamide to ablate CAR T cells is an effective strategy to mitigate steroid-refractory NINTs.

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