Conflicts of interest Dr Beck reports research funding from the National Institute of Allergy and Infectious Diseases of the National Institutes of Health (Award Numbers U01AI152011 and U19AI117673), is a consultant for Allakos, Amgen, Arena Pharmaceuticals, Cara Therapeutics, Dermtech, Evelo Biosciences, Galderma, GlaxoSmithKline, Incyte, Janssen, LEO Pharma, Merck, Numab Therapeutics, Pfizer, Rapt Therapeutics, Regeneron, Ribon Therapeutics, Sanofi or Genzyme, Sanofi-Aventis, Stealth Biotherapeutics, Trevi Therapeutics, Union Therapeutics, and Xencor, and has served as an investigator for Abbvie, Astra-zeneca, Dermtech, Kiniksa, Pfizer, Regeneron, Ribon Therapeutics, and Sanofi clinical trials. Dr Järvinen reports research funding from the National Institute of Allergy and Infectious Diseases of the National Institutes of Health (Award Numbers U01AI131344 and R01AI163571), is a consultant for Janssen and Harmony or Mill Care, and is an investigator on Aimmune, DBV, and Siolta trials. Dr Herman has no conflicts of interests to declare.