Invigorating discovery and clinical translation of aging biomarkers

Erik Jacques¹, Chiara Herzog^{2

3

4}, Kejun Ying^{1

2

5}, Alan Tomusiak⁶, Jessica Kasamoto⁷, Raghav Sehgal⁷, Seth Paulson⁸, Julian Reinhard⁹, Jakob Träuble¹⁰, Waylon J Hastings^{11

12}, Alexander Tyshkovskiy¹, Sara Hägg^{2

13}, John C Earls⁶, Christian E Behrens¹⁴, Jessica Lasky-Su^{2

15}, Gavin Zhou^{16

17}, Eric Morgen¹⁸, John S Tsang^{19

20}, Riccardo E Marioni^{2

21}, Xiao-Jun Ma²², Alexandra Stolzing²³, Christin Glorioso²⁴, Jonathan S Gootenberg^{25

26

27}, Omar O Abudayyeh^{26

27

28}, M Austin Argentieri^{29

30

31}, Raymond H Mak^{32

33}, Lynne S Cox^{34

35}, Andrew S Brack³⁶, Gordan Lauc³⁷, David Furman^{2

6

38}, Jason D Buenrostro^{39

40}, Björn Schumacher^{41

42}, Jamie N Justice^{2

43

44}, Tina Woods^{45

46}, David Gobel⁸, Viviana I Perez⁴⁷, David A Sinclair⁴⁸, Andrea B Maier^{2

49

50}, Nir Barzilai^{2

51

52}, Michael P Snyder^{2

53

54}, Tony Wyss-Coray^{55

56}, Steve Horvath^{2

57}, Luigi Ferrucci^{2

58}, Jesse R Poganik^{59

60}, Mahdi Moqri^{61

62

63

64}, Vadim N Gladyshev^{65

66}

Affiliations

¹ Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
² Biomarkers of Aging Consortium.
³ University of Innsbruck, Innsbruck, Austria.
⁴ University College London, London, UK.
⁵ T. H. Chan School of Public Health, Harvard University, Boston, MA, USA.
⁶ Buck Institute for Research on Aging, Novato, CA, USA.
⁷ Program in Computational Biology and Bioinformatics, Yale University, New Haven, CT, USA.
⁸ Methuselah Foundation.
⁹ Evotec SE.
¹⁰ Department of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge, UK.
¹¹ Institute for Advancing Health Through Agriculture, Texas A&M University, College Station, TX, USA.
¹² Department of Nutrition, Texas A&M University, College Station, TX, USA.
¹³ Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Solna, Sweden.
¹⁴ Bayer Consumer Health.
¹⁵ Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
¹⁶ Regenerative Bio Inc, Hangzhou, China.
¹⁷ Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou, China.
¹⁸ BioAge Labs, Richmond, CA, USA.
¹⁹ Center for Systems and Engineering Immunology, Departments of Immunobiology and Biomedical Engineering, Yale University School of Medicine, New Haven, CT, USA.
²⁰ Chan Zuckerberg Biohub New York, New Haven, CT, USA.
²¹ Centre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.
²² Alamar Biosciences, Inc, Fremont, CA, USA.
²³ Loughborough University, Loughborough, UK.
²⁴ NeuroAge Therapeutics.
²⁵ Department of Medicine, Division of Engineering in Medicine Brigham and Women's Hospital Harvard Medical School, Boston, MA, USA.
²⁶ Gene and Cell Therapy Institute Mass General Brigham, Cambridge, MA, USA.
²⁷ Center for Virology and Vaccine Research Beth Israel Deaconess Medical Center Harvard Medical School, Boston, MA, USA.
²⁸ Department of Medicine Division of Engineering in Medicine Brigham and Women's Hospital Harvard Medical School, Boston, MA, USA.
²⁹ Massachusetts General Hospital, Boston, MA, USA.
³⁰ Broad Institute of MIT and Harvard, Cambridge, MA, USA.
³¹ Harvard Medical School, Boston, MA, USA.
³² Department of Radiation Oncology, Dana-Farber/Brigham Cancer Center, Boston, MA, USA.
³³ Mass General Brigham Artificial Intelligence in Medicine Program, Boston, MA, USA.
³⁴ Department of Biochemistry, University of Oxford, Oxford, UK.
³⁵ Wellcome Leap Dynamic Resilience.
³⁶ Advanced Research Projects Agency for Health (ARPA-H).
³⁷ Genos Glycoscience Research Laboratory, Faculty of Pharmacy and Biochemistry, University of Zagreb, Zagreb, Croatia.
³⁸ Stanford 1000 Immunomes Project, Stanford University School of Medicine, Stanford, CA, USA.
³⁹ Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA.
⁴⁰ Gene Regulation Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
⁴¹ Institute for Genome Stability in Aging and Disease, University Hospital and University of Cologne, Cologne, Germany.
⁴² Cologne Excellence Cluster for Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany.
⁴³ XPRIZE Foundation, Culver City, CA, USA.
⁴⁴ Department of Internal Medicine - Gerontology and Geriatrics, Wake Forest School of Medicine, Winston-, Salem, NC, USA.
⁴⁵ Collider Health.
⁴⁶ International Institute of Longevity.
⁴⁷ Hevolution Foundation.
⁴⁸ Department of Genetics, Harvard Medical School, Boston, MA, USA.
⁴⁹ Department of Human Movement Sciences, Faculty of Behavioural and Movement Sciences, Amsterdam Movement Sciences, Vrije Universiteit, Amsterdam, Netherlands.
⁵⁰ NUS Academy for Healthy Longevity, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
⁵¹ Institute for Aging Research, Department of Medicine, Albert Einstein College of Medicine, Bronx, NY, USA.
⁵² Department of Genetics, Albert Einstein College of Medicine, Bronx, NY, USA.
⁵³ Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA.
⁵⁴ Stanford Center for Genomics and Personalized Medicine, Stanford, CA, USA.
⁵⁵ Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA.
⁵⁶ The Phil and Penny Knight Initiative for Brain Resilience, Stanford University, Stanford, CA, USA.
⁵⁷ Altos Labs, Cambridge, UK.
⁵⁸ Intramural Research Program of the National Institute on Aging, NIH, Baltimore, MD, USA.
⁵⁹ Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. jpoganik@bwh.harvard.edu.
⁶⁰ Biomarkers of Aging Consortium, . jpoganik@bwh.harvard.edu.
⁶¹ Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. mmoqri@bwh.harvard.edu.
⁶² Biomarkers of Aging Consortium, . mmoqri@bwh.harvard.edu.
⁶³ Department of Genetics, School of Medicine, Stanford University, Stanford, CA, USA. mmoqri@bwh.harvard.edu.
⁶⁴ Department of Obstetrics and Gynecology, School of Medicine, Stanford University, Stanford, CA, USA. mmoqri@bwh.harvard.edu.
⁶⁵ Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. vgladyshev@bwh.harvard.edu.
⁶⁶ Biomarkers of Aging Consortium, . vgladyshev@bwh.harvard.edu.

PMID: 40164770
DOI: 10.1038/s43587-025-00838-w

Invigorating discovery and clinical translation of aging biomarkers

Erik Jacques et al. Nat Aging. 2025 Apr.

. 2025 Apr;5(4):539-543.

doi: 10.1038/s43587-025-00838-w.

Authors

Affiliations

¹ Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
² Biomarkers of Aging Consortium.
³ University of Innsbruck, Innsbruck, Austria.
⁴ University College London, London, UK.
⁵ T. H. Chan School of Public Health, Harvard University, Boston, MA, USA.
⁶ Buck Institute for Research on Aging, Novato, CA, USA.
⁷ Program in Computational Biology and Bioinformatics, Yale University, New Haven, CT, USA.
⁸ Methuselah Foundation.
⁹ Evotec SE.
¹⁰ Department of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge, UK.
¹¹ Institute for Advancing Health Through Agriculture, Texas A&M University, College Station, TX, USA.
¹² Department of Nutrition, Texas A&M University, College Station, TX, USA.
¹³ Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Solna, Sweden.
¹⁴ Bayer Consumer Health.
¹⁵ Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
¹⁶ Regenerative Bio Inc, Hangzhou, China.
¹⁷ Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou, China.
¹⁸ BioAge Labs, Richmond, CA, USA.
¹⁹ Center for Systems and Engineering Immunology, Departments of Immunobiology and Biomedical Engineering, Yale University School of Medicine, New Haven, CT, USA.
²⁰ Chan Zuckerberg Biohub New York, New Haven, CT, USA.
²¹ Centre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.
²² Alamar Biosciences, Inc, Fremont, CA, USA.
²³ Loughborough University, Loughborough, UK.
²⁴ NeuroAge Therapeutics.
²⁵ Department of Medicine, Division of Engineering in Medicine Brigham and Women's Hospital Harvard Medical School, Boston, MA, USA.
²⁶ Gene and Cell Therapy Institute Mass General Brigham, Cambridge, MA, USA.
²⁷ Center for Virology and Vaccine Research Beth Israel Deaconess Medical Center Harvard Medical School, Boston, MA, USA.
²⁸ Department of Medicine Division of Engineering in Medicine Brigham and Women's Hospital Harvard Medical School, Boston, MA, USA.
²⁹ Massachusetts General Hospital, Boston, MA, USA.
³⁰ Broad Institute of MIT and Harvard, Cambridge, MA, USA.
³¹ Harvard Medical School, Boston, MA, USA.
³² Department of Radiation Oncology, Dana-Farber/Brigham Cancer Center, Boston, MA, USA.
³³ Mass General Brigham Artificial Intelligence in Medicine Program, Boston, MA, USA.
³⁴ Department of Biochemistry, University of Oxford, Oxford, UK.
³⁵ Wellcome Leap Dynamic Resilience.
³⁶ Advanced Research Projects Agency for Health (ARPA-H).
³⁷ Genos Glycoscience Research Laboratory, Faculty of Pharmacy and Biochemistry, University of Zagreb, Zagreb, Croatia.
³⁸ Stanford 1000 Immunomes Project, Stanford University School of Medicine, Stanford, CA, USA.
³⁹ Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA.
⁴⁰ Gene Regulation Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
⁴¹ Institute for Genome Stability in Aging and Disease, University Hospital and University of Cologne, Cologne, Germany.
⁴² Cologne Excellence Cluster for Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany.
⁴³ XPRIZE Foundation, Culver City, CA, USA.
⁴⁴ Department of Internal Medicine - Gerontology and Geriatrics, Wake Forest School of Medicine, Winston-, Salem, NC, USA.
⁴⁵ Collider Health.
⁴⁶ International Institute of Longevity.
⁴⁷ Hevolution Foundation.
⁴⁸ Department of Genetics, Harvard Medical School, Boston, MA, USA.
⁴⁹ Department of Human Movement Sciences, Faculty of Behavioural and Movement Sciences, Amsterdam Movement Sciences, Vrije Universiteit, Amsterdam, Netherlands.
⁵⁰ NUS Academy for Healthy Longevity, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
⁵¹ Institute for Aging Research, Department of Medicine, Albert Einstein College of Medicine, Bronx, NY, USA.
⁵² Department of Genetics, Albert Einstein College of Medicine, Bronx, NY, USA.
⁵³ Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA.
⁵⁴ Stanford Center for Genomics and Personalized Medicine, Stanford, CA, USA.
⁵⁵ Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA.
⁵⁶ The Phil and Penny Knight Initiative for Brain Resilience, Stanford University, Stanford, CA, USA.
⁵⁷ Altos Labs, Cambridge, UK.
⁵⁸ Intramural Research Program of the National Institute on Aging, NIH, Baltimore, MD, USA.
⁵⁹ Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. jpoganik@bwh.harvard.edu.
⁶⁰ Biomarkers of Aging Consortium, . jpoganik@bwh.harvard.edu.
⁶¹ Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. mmoqri@bwh.harvard.edu.
⁶² Biomarkers of Aging Consortium, . mmoqri@bwh.harvard.edu.
⁶³ Department of Genetics, School of Medicine, Stanford University, Stanford, CA, USA. mmoqri@bwh.harvard.edu.
⁶⁴ Department of Obstetrics and Gynecology, School of Medicine, Stanford University, Stanford, CA, USA. mmoqri@bwh.harvard.edu.
⁶⁵ Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. vgladyshev@bwh.harvard.edu.
⁶⁶ Biomarkers of Aging Consortium, . vgladyshev@bwh.harvard.edu.

PMID: 40164770
DOI: 10.1038/s43587-025-00838-w

No abstract available

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Conflict of interest statement

Competing interests: J.R. is a scientist with Evotec SE. C.E.B. is Associate Director Medical Affairs at Bayer Consumer Health. G.Z. is co-founder & CTO at Regenerative Bio. E.M. is co-founder & COO at BioAge Labs. X.-J.M. is CTO at Alamar Biosciences. C.G. is co-founder and CEO of NeuroAge Therapeutics. The remaining authors declare no competing interests.

References

1. Moqri, M. et al. Cell 186, 3758–3775 (2023). - DOI - PubMed - PMC
1. Moqri, M. et al. Nat. Med. 30, 360–372 (2024). - DOI - PubMed - PMC
1. Herzog, C. M. S. et al. Nat. Aging 4, 1372–1383 (2024). - DOI - PubMed
1. Oh, H. S. H. et al. Nature 624, 164–172 (2023). - DOI - PubMed - PMC
1. Argentieri, M. A. et al. Nat. Med. 30, 2450–2460 (2024). - DOI - PubMed - PMC

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AG065403/U.S. Department of Health & Human Services | NIH | National Institute on Aging (U.S. National Institute on Aging)

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Invigorating discovery and clinical translation of aging biomarkers

Affiliations

Invigorating discovery and clinical translation of aging biomarkers

Authors

Affiliations

Conflict of interest statement

References

Grants and funding

LinkOut - more resources

Full Text Sources