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Review
. 2025 Jul 1;34(4):291-296.
doi: 10.1097/MNH.0000000000001074. Epub 2025 Apr 1.

The role of osteopontin in chronic kidney disease-mineral bone disorder

Eduardo J Duque  1 , Cecilia Giachelli  2 , Rosa M A Moysés  3
Affiliations
Review

The role of osteopontin in chronic kidney disease-mineral bone disorder

Eduardo J Duque et al. Curr Opin Nephrol Hypertens. .

Abstract

Purpose of review: Chronic kidney disease-mineral bone disorder (CKD-MBD) is associated with several adverse outcomes, including bone fragility and sarcopenia. Identification of new agents mitigating systemic damage related to uremia is critical and needed to unveil pathways implicated in CKD-MBD.

Recent findings: Osteopontin (OPN) is involved in different physiological and pathological processes and works as a bridge connecting several systems. It may serve as a biomarker for many diseases, including human cancers, neurodegenerative disorders and autoimmune diseases. OPN has been implicated in disturbances of bone mineralization and remodeling, and has an interplay with parathyroid hormone and FGF23 in experimental models. In patients with CKD and severe hyperparathyroidism, OPN expression in muscle tissue has been linked to worse functionality and local inflammation, which is partially reverted after parathyroidectomy.

Summary: Future studies could confirm the role of OPN as a biomarker in nephrology. Greater understanding of its role in CKD-MBD will help us define a better therapeutic strategy in patients with CKD.

Keywords: chronic kidney disease-mineral bone disorder; inflammation; osteopontin; phosphate.

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References

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