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. 2025 Apr 1;15(1):47.
doi: 10.1186/s13613-025-01455-x.

Automatic continuous P0.1 measurements during weaning from mechanical ventilation: a clinical study

Flora Delamaire  1   2 , Maamar Adel  3   4 , Guillot Pauline  3   4 , Quelven Quentin  3   4 , Coirier Valentin  3   4 , Painvin Benoit  3   4 , Tadie Jean-Marc  3   4   5 , Terzi Nicolas  3   4   5 , Gacouin Arnaud  3   4   5
Affiliations

Automatic continuous P0.1 measurements during weaning from mechanical ventilation: a clinical study

Flora Delamaire et al. Ann Intensive Care. .

Erratum in

Abstract

Background: In critically ill patients, weaning from mechanical ventilation (MV) includes spontaneous breathing trial (SBT) usually followed by a reventilation period in order to recover from the alveolar derecruitement induced by the SBT. The measurement of occlusion pressure during the first 100 ms of an airway occlusion (P0.1) one of the non-invasive tools available for estimating the respiratory drive, is a determinant of patient respiratory effort. This clinical study explores the use of non-invasive continuous monitoring of occlusion pressure automatically calculated by ventilators in the first 100 ms of airway occlusion (P0.1 vent) during SBT and reventilation periods. The study aimed to investigate patient or respirator factors influencing P0.1 vent as well as the association of P0.1 vent values with extubation success or failure.

Patients and methods: This prospective observational study, conducted from February 2022 to April 2023, included adult patients intubated for more than 24 h and screened for extubation weaning. SBTs were performed for one hour with zero pressure support and zero end-expiratory pressure (PS0 ZEEP). Reventilation followed for an hour with pressure support (8-12 cmH2O) and PEEP (5 cmH2O). Data included patient characteristics, ventilator parameters and extubation outcomes.

Results: The study involved 224 measurements from 212 patients, with 157 successful extubations, 46 extubation failures at day 7 and 21 SBT failures. P0.1 vent mean values were significantly higher for extubation failures and SBT failures compared to successful extubations (p < 0.001). Delta P0.1 vent ((P0.1 vent reventilation - P0.1 vent SBT)/ P0.1 vent SBT) was significantly different according to whether extubation was a success or a failure: 0.21 (0.02-0.62) cm H2O vs. P0.1 vent vs. 1.12 (0.54-2.38) cm H2O; p < 0.0001 respectively. Values significantly differed in both the SBT and the reventilation periods whether or not patients had previous ARDS: 1.08 (0.70; 2.02) cmH2O vs. 0.80 (0.54; 1.28) cmH2O respectively (p = 0.003). Noteworthy, P0.1 vent values were influenced by airway humidification systems (0.92 (0.57; 1.54) cmH2O with humidification vs. 1.27 (0.91; 2.24) cmH2O without, p = 0.003).

Conclusion: The delta of P0.1vent values between SBT and reventilation are higher for patients who fail extubation, especially for those who had ARDS. While elevated P0.1 vent values were associated with extubation failure, the overlap in values limits its usefulness as a reliable predictor.

Keywords: Mechanical ventilation weaning; P0.1 automatic measurement; Spontaneous breathing trial; Ventilator accuracy.

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Conflict of interest statement

Declarations. Ethics approval and consent to participate: This observational study was approved by the institutional ethics committee (number 22.216) of Rennes, Pontchaillou university hospital. Patients were informed of their inclusion in the study and informed consent was waived as per French law. Consent for publication: Not applicable. Competing interests: NT reports personal fees from Fisher Paykel outside the submitted work. NT is supported by Pfizer for attending meetings and/or travel and non-financial supports from Gilead outside this work. All other authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
Data collection
Fig. 2
Fig. 2
Flow chart of patients
Fig. 3
Fig. 3
Automated measurements of P0.1 (P0.1vent) recorded at 0, 15, 30, 45, and 60 min during SBT (PS 0 ZEEP) (A) and reventilation period (PS = 8–12 cmH2O and PEEP = 5 cmH2O) (B) in SBT failures, controls, and successful and failed extubations. Box plot: Solid line indicates median, box indicates the interquartile ranges, and whiskers maximum and minimum
Fig. 4
Fig. 4
P0.1 vent recorded at 0, 15, 30, 45 and 60 min during SBT (PS 0 ZEEP) and reventilation period (PS = 8–12 cmH2O and PEEP = 5 cmH2O) compared between patients who failed and succeded extubation at day 7
Fig. 5
Fig. 5
P0.1vent recorded at 0, 15, 30, 45, and 60 min during SBT (PS 0 ZEEP) and reventilation period (PS = 8–12 cmH2O and PEEP = 5 cmH2O) compared between patients with and without ARDS. Box plot: Solid line indicates median, box indicates the interquartile ranges, and whiskers maximum and minimum
See this image and copyright information in PMC

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