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. 2025 May;43(5):672-676.

doi: 10.1038/s41587-025-02623-x.

The emerging landscape of engineered bacteria cancer therapies

Edward R Ballister^#^{1

2}, Alexander Michels^#¹, Rosa L Vincent^#^{1

3}, Lior Kreindler¹, Sreyan Chowdhury¹, Samik Upadhaya⁴, Ana Rosa Saez-Ibañez⁴, Tao Tu⁵, Juraj Gottweis⁵, Tal Danino^{6

7

8}

Affiliations

Affiliations

¹ Department of Biomedical Engineering, Columbia University, New York, NY, USA.
² Department of Microbiology and Immunology, Vagelos College of Physicians and Surgeons of Columbia University, New York, NY, USA.
³ Center for Gene Therapy, Baylor College of Medicine, Houston, TX, USA.
⁴ Cancer Research Institute, New York, NY, USA.
⁵ Google Research, Mountain View, CA, USA.
⁶ Department of Biomedical Engineering, Columbia University, New York, NY, USA. tal.danino@columbia.edu.
⁷ Herbert Irving Comprehensive Cancer Center, Columbia University, New York, NY, USA. tal.danino@columbia.edu.
⁸ Data Science Institute, Columbia University, New York, NY, USA. tal.danino@columbia.edu.

^# Contributed equally.

PMID: 40169920
DOI: 10.1038/s41587-025-02623-x

The emerging landscape of engineered bacteria cancer therapies

Edward R Ballister et al. Nat Biotechnol. 2025 May.

. 2025 May;43(5):672-676.

doi: 10.1038/s41587-025-02623-x.

Authors

Edward R Ballister^#^{1

2}, Alexander Michels^#¹, Rosa L Vincent^#^{1

3}, Lior Kreindler¹, Sreyan Chowdhury¹, Samik Upadhaya⁴, Ana Rosa Saez-Ibañez⁴, Tao Tu⁵, Juraj Gottweis⁵, Tal Danino^{6

7

8}

Affiliations

¹ Department of Biomedical Engineering, Columbia University, New York, NY, USA.
² Department of Microbiology and Immunology, Vagelos College of Physicians and Surgeons of Columbia University, New York, NY, USA.
³ Center for Gene Therapy, Baylor College of Medicine, Houston, TX, USA.
⁴ Cancer Research Institute, New York, NY, USA.
⁵ Google Research, Mountain View, CA, USA.
⁶ Department of Biomedical Engineering, Columbia University, New York, NY, USA. tal.danino@columbia.edu.
⁷ Herbert Irving Comprehensive Cancer Center, Columbia University, New York, NY, USA. tal.danino@columbia.edu.
⁸ Data Science Institute, Columbia University, New York, NY, USA. tal.danino@columbia.edu.

^# Contributed equally.

PMID: 40169920
DOI: 10.1038/s41587-025-02623-x

No abstract available

PubMed Disclaimer

Conflict of interest statement

Competing interests: T.D. and S.C. have a financial interest in GenCirq Inc.

References

1. Forbes, N. S. Nat. Rev. Cancer 10, 785–794 (2010). - DOI - PubMed - PMC
1. Zhou, S., Gravekamp, C., Bermudes, D. & Liu, K. Nat. Rev. Cancer 18, 727–743 (2018). - DOI - PubMed - PMC
1. Duong, M. T.-Q., Qin, Y., You, S.-H. & Min, J.-J. Exp. Mol. Med. 51, 1–15 (2019). - DOI - PubMed
1. Sieow, B. F.-L., Wun, K. S., Yong, W. P., Hwang, I. Y. & Chang, M. W. Trends Cancer 7, 447–464 (2021). - DOI - PubMed
1. Lynch, J. P., Goers, L. & Lesser, C. F. Trends Pharmacol. Sci. 43, 772–786 (2022). - DOI - PubMed - PMC

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