The Hallmarks of Cancer as Eco-Evolutionary Processes

Ranjini Bhattacharya^{1

2

3}, Stanislav S Avdieiev^{1

2}, Anuraag Bukkuri^{1

2

4

5

6}, Christopher J Whelan^{1

7

8}, Robert A Gatenby^{1

2

9}, Kenneth Y Tsai^{1

10

11}, Joel S Brown^{1

2

8}

Affiliations

¹ Cancer Biology and Evolution Program, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.
² Department of Integrated Mathematical Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.
³ Department of Cancer Biology, University of South Florida, Tampa, Florida.
⁴ Department of Computational and Systems Biology, University of Pittsburgh, Pittsburgh, Pennsylvania.
⁵ UPMC Hillman Cancer Center, Pittsburgh, Pennsylvania.
⁶ Center for Evolutionary Biology and Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania.
⁷ Department of Metabolism and Physiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.
⁸ Department of Biological Sciences, University of Illinois at Chicago, Chicago, Illinois.
⁹ Department of Radiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.
¹⁰ Department of Tumor Microenvironment & Metastasis, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.
¹¹ Department of Pathology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.

PMID: 40170539
DOI: 10.1158/2159-8290.CD-24-0861

The Hallmarks of Cancer as Eco-Evolutionary Processes

Ranjini Bhattacharya et al. Cancer Discov. 2025.

. 2025 Apr 2;15(4):685-701.

doi: 10.1158/2159-8290.CD-24-0861.

Authors

Affiliations

¹ Cancer Biology and Evolution Program, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.
² Department of Integrated Mathematical Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.
³ Department of Cancer Biology, University of South Florida, Tampa, Florida.
⁴ Department of Computational and Systems Biology, University of Pittsburgh, Pittsburgh, Pennsylvania.
⁵ UPMC Hillman Cancer Center, Pittsburgh, Pennsylvania.
⁶ Center for Evolutionary Biology and Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania.
⁷ Department of Metabolism and Physiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.
⁸ Department of Biological Sciences, University of Illinois at Chicago, Chicago, Illinois.
⁹ Department of Radiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.
¹⁰ Department of Tumor Microenvironment & Metastasis, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.
¹¹ Department of Pathology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.

PMID: 40170539
DOI: 10.1158/2159-8290.CD-24-0861

Abstract

Viewing the hallmarks as a sequence of adaptations captures the "why" behind the "how" of the molecular changes driving cancer. This eco-evolutionary view distils the complexity of cancer progression into logical steps, providing a framework for understanding all existing and emerging hallmarks of cancer and developing therapeutic interventions.

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The Hallmarks of Cancer as Eco-Evolutionary Processes

Affiliations

The Hallmarks of Cancer as Eco-Evolutionary Processes

Authors

Affiliations

Abstract

MeSH terms

Grants and funding

LinkOut - more resources

Full Text Sources

Medical