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. 2025 Mar 18:16:1552269.
doi: 10.3389/fphys.2025.1552269. eCollection 2025.

Correlation between cardiometabolic index and psoriasis: a cross-sectional analysis using NHANES data

Mengxue Li  1 , Yixiao Gan  1 , Hong Cheng  1 , Zhicheng Wang  1
Affiliations

Correlation between cardiometabolic index and psoriasis: a cross-sectional analysis using NHANES data

Mengxue Li et al. Front Physiol. .

Abstract

Background: Psoriasis is closely associated with metabolic health. The Cardiometabolic Index (CMI) is an innovative and easily obtainable metric employed to assess cardiometabolic health. This study aims to examine the possible relationship between CMI and psoriasis.

Methods: Data from four successive cycles of the National Health and Nutrition Examination Survey (NHANES) conducted between 2003-2004 and 2009-2014 were employed. This encompassed adults with self-reported psoriasis diagnoses and comprehensive information necessary for calculating the CMI. The calculation formula for CMI is Triglycerides (TG)/High-density lipoprotein cholesterol (HDL-C) × WHtR (WHtR = waist circumference/height). A multivariable logistic regression model was utilized to examine the linear relationship between CMI and psoriasis. Subgroup analyses were conducted to investigate potential contributing factors. The linear relationship was further established using smooth curve fitting.

Results: This study, utilizing NHANES data, comprised a cohort of 7,327 American adults. The multivariable logistic regression analysis indicated that in the fully adjusted model, people with the greatest CMI had a 71% increased probability of psoriasis relative to those with the lowest CMI (OR = 1.71; 95% CI, 1.11-2.61, P < 0.05). Smooth curve fitting demonstrated a linear connection between CMI and psoriasis (P < 0.05). The subgroup analysis revealed no significant interactions between CMI and specific subgroups (all interactions P > 0.05).

Conclusion: Our research indicates a substantial linear correlation between CMI and psoriasis in American adults. This method facilitates the identification of groups at increased risk for psoriasis, therefore guiding therapeutic solutions and public health activities to improve metabolic and dermatological health outcomes.

Keywords: NHANES; cardiometabolic index; cross-sectional study; multivariate logic analysis; psoriasis.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
Diagram of participant enrollment process.
FIGURE 2
FIGURE 2
The association between CMI and psoriasis. The smoothed curve fit between the variables is shown as a solid red line, with the 95% CIs of the fitted results indicated by the blue line. Controlled attenuation parameter. CMI, cardiometabolic index.
FIGURE 3
FIGURE 3
Subgroup analysis for the association between CMI and psoriasis fully adjusted. In the subgroup analyses, the models were not tuned for the stratification variables themselves. PIR, ratio of family income to poverty. BMI, body mass index. CMI, cardiometabolic index.
See this image and copyright information in PMC

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