Adverse Pregnancy Outcomes and N-Terminal Pro-Brain Natriuretic Peptide Levels 2 to 7 Years After Delivery: The nuMoM2b Heart Health Study

doi:10.1001/jamacardio.2025.0325

. 2025 May 1;10(5):514-516.

doi: 10.1001/jamacardio.2025.0325.

Adverse Pregnancy Outcomes and N-Terminal Pro-Brain Natriuretic Peptide Levels 2 to 7 Years After Delivery: The nuMoM2b Heart Health Study

Priya M Freaney^{1

2}, Xiaoning Huang², Lucia C Petito², William A Grobman³, Janet Catov⁴, Alisse Hauspurg⁴, C Noel Bairey Merz⁵, Natalie Bello⁵, Jin Kyung Kim⁶, Abbi Lane⁷, David M Haas⁸, Lisa D Levine⁹, Rebecca B McNeil¹⁰, Eliza Miller¹¹, George Saade¹², Lauren Theilen¹³, Lynn M Yee¹⁴, Jasmina Varagic¹⁴, Brian Mercer¹⁵, Uma Reddy¹⁶, Donald M Lloyd-Jones^{1

2}, Philip Greenland^{1

2}, Sadiya S Khan^{1

2

17}; National Heart, Lung, and Blood Institute nuMoM2b Heart Health Study Network

Collaborators, Affiliations

Collaborators

National Heart, Lung, and Blood Institute nuMoM2b Heart Health Study Network:
Wendy Dalton, Judette M Louis, Brian M Mercer, LuAnn Polito, Jay Iams, Cheryl Latimer, Robert C Basner, Michelle DiVito, Karin Fuchs, Chia-Ling Nhan-Chang, Ameneh Onativia, Caroline Torres, Ronald Wapner, Matthew K Hoffman, Stephanie Lynch, Maurice Davis, Uma M Reddy, Marian Willinger, Daniel Mobley, Susan Redline, Susan Surovec, Julianne Ulanski, Shannon Barnes, Tatiana Foroud, David M Haas, Catherine L McCormick, Emily Perkins, Frank P Schubert, Alicia Winters, Aaron Laposky, Peggy Campbell, William A Grobman, Alan M Peaceman, Jessica S Shepard, Crystal N Williams, Phyllis C Zee, Barbara V Alexander, Martha J DeCain, Holly L Franklin, Christopher Griggs, Tommy E Holder Jr, Shannon Hunter, Matthew A Koch, Deborah W McFadden, Corette B Parker, Venkat Yetukuri, Judith H Chung, Michael P Nageotte, Valerie Pham, Manuel Porto, Pamela J Rumney, Pathik D Wadhwa, Deborah A Wing, Brittany Araujo, Michal Elovitz, Jack Ludmir, Samuel Parry, Mary Peters, Grace Pien, Melissa Bickus, Steve N Caritis, Ashi R Daftary, Stephen P Emery, Francesca L Facco, Hyagriv N Simhan, Paul D Speer, George R Saade, Kelly Christensen, M Sean Esplin, Linda Meadows, Valerie Morby, Julie Postma, Robert M Silver, Melanie Williams, Ashish Aneja, Kelly Gibson, Jessica Pippen, Bonnie Rosolowski, Laniece Thomas, C Noel Bairey Merz, Natalie Bello, Ian Brower, Maria Marroquin, Jenna Maughan, Nathan Sela, Brandon Wanke, Eileen Yu, Casandra Almonte, Cande Ananth, Veronica Barcelona, Whitney Booker, Jeremy Chiu, Kirsten Cleary, Nathalie De La Cruz, Brandy Firman, Yessenia Gutierrez, Noora Haghighi, Carla Haro, Jennifer Haythe, Tal Korem, Eliza Miller, Belgica Peguero, Uma Reddy, Jeimy Rosado Feliz, Qi Yan, Carrie Kitto, Jennifer Nava, Amy Staples, Tetsuya Kawakita, Cathy Spong, Michael Honigberg, Erica-Jane Maro, Jessica Roby-Fout, Christina Scifres, Hannah Shockley, Ligia Vasquez-Hout, Haley Schmidt, Brittany Yeley, Anum Minhas, Victoria L Pemberton, Michael Twery, Jasmina Varagic, Philip Greenland, Bonnie J Kane, Kiarri Kershaw, Sadiya Khan, Minjee Kim, Elizabeth Rangel, Laura Seegmiller, Lynn M Yee, Alicia Lynch, McKenzie Jancsura, Courtney Lynch, Kartik Venkatesh, Jiqiang Wu, Carla Bann, Benjamin Carper, Emma Crenshaw, Brian Erman, Katie Fain, Carl Fisher, Sean Hanlon, Mallory Harris, Joey Hoellerich, Karen Kesler, Nick Kinsey, David Leblond, Derek Marsh, Taya McMillan, Rebecca B McNeil, Heather Meier, Janet Moore, Callie Riggs, Sridevi Sattaluri, Emily W Thomas, Vanessa Thorsten, Nathan Vandergrift, Roger Williams, Yii-Der Ida Chen, Phuong Linh L Huỳnh, Jin Kyung Kim, Nikka Shahrokni, Lizette Spiers, Amanda Thornton, Jesi Zavala, Caitlyn Hendrickson, Abbi Lane, Caroline Huang, Andrea Kozai, Lisa Levine, Jennifer Lewey, Meaghan McCabe, Maria Monterroso, Nadia Ngom, Keri Simonette, Saisahana Subburaj, Fatoumata Sy, Ainsley Bradbury, Allison Baxter, Lisa Bodnar, Samantha Bryan, Janet Catov, Christiana Ekekwe, Abigail Evans, Alisse Hauspurg, Lacey Heinsberg, Kimberly Huber, Michele Levine, Victoria Lopata, Christofer Price, Mitali Ray, Jill Tarr, Alexis Thrower, Julia Whiteleather, Nathan Blue, Maggie Cook, Danielle Heil, Torri Metz, Josh Oliver, Dexter Patterson, Karen Schliep, Lauren Theilen, Sharla Aldous, Stacey Breeze, Lindsey Carlson, Sandi Dellerman, Holly Evans, Bri Hobbs, Jessica Johnson, Jake Krong, Diana Magana, Catherine Meadows, Rachel Moore, Michael Nunley, Kristin Orton, Midra Pederson, Sara St Hilaire, Kailey Tingey, Nic Unsworth, Kristin Hansen, Claudia Korcarz, Bethany Barone Gibbs, Devin Lai, Sarah Modlin

Affiliations

¹ Division of Cardiology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
² Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
³ Department of Obstetrics and Gynecology, Ohio State University College of Medicine, Columbus.
⁴ Department of Obstetrics, Gynecology, and Reproductive Services, Magee-Womens Research Institute, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
⁵ Department of Cardiology, Barbra Streisand Women's Heart Center, Smidt Cedars-Sinai Heart Institute, Los Angeles, California.
⁶ Department of Obstetrics and Gynecology, University of California, Irvine.
⁷ Department of Applied Exercise Science, School of Kinesiology, University of Michigan, Ann Arbor.
⁸ Department of Obstetrics and Gynecology, Indiana University School of Medicine, Indianapolis.
⁹ Department of Obstetrics and Gynecology, University of Pennsylvania Perelman School of Medicine, Philadelphia.
¹⁰ RTI International, Research Triangle Park, North Carolina.
¹¹ Department of Neurology, Columbia University, New York, New York.
¹² Department of Obstetrics and Gynecology, University of Texas Medical Branch, Galveston, Galveston.
¹³ Department of Obstetrics and Gynecology, University of Utah, Salt Lake City.
¹⁴ Department of Obstetrics and Gynecology, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
¹⁵ Case Western Reserve University School of Medicine, Cleveland, Ohio.
¹⁶ Department of Obstetrics and Gynecology, Columbia University, New York, New York.
¹⁷ Associate Editor, JAMA Cardiology.

PMID: 40172904
PMCID: PMC11966469 (available on 2026-04-02)
DOI: 10.1001/jamacardio.2025.0325

Adverse Pregnancy Outcomes and N-Terminal Pro-Brain Natriuretic Peptide Levels 2 to 7 Years After Delivery: The nuMoM2b Heart Health Study

Priya M Freaney et al. JAMA Cardiol. 2025.

. 2025 May 1;10(5):514-516.

doi: 10.1001/jamacardio.2025.0325.

Authors

Collaborators

National Heart, Lung, and Blood Institute nuMoM2b Heart Health Study Network:
Wendy Dalton, Judette M Louis, Brian M Mercer, LuAnn Polito, Jay Iams, Cheryl Latimer, Robert C Basner, Michelle DiVito, Karin Fuchs, Chia-Ling Nhan-Chang, Ameneh Onativia, Caroline Torres, Ronald Wapner, Matthew K Hoffman, Stephanie Lynch, Maurice Davis, Uma M Reddy, Marian Willinger, Daniel Mobley, Susan Redline, Susan Surovec, Julianne Ulanski, Shannon Barnes, Tatiana Foroud, David M Haas, Catherine L McCormick, Emily Perkins, Frank P Schubert, Alicia Winters, Aaron Laposky, Peggy Campbell, William A Grobman, Alan M Peaceman, Jessica S Shepard, Crystal N Williams, Phyllis C Zee, Barbara V Alexander, Martha J DeCain, Holly L Franklin, Christopher Griggs, Tommy E Holder Jr, Shannon Hunter, Matthew A Koch, Deborah W McFadden, Corette B Parker, Venkat Yetukuri, Judith H Chung, Michael P Nageotte, Valerie Pham, Manuel Porto, Pamela J Rumney, Pathik D Wadhwa, Deborah A Wing, Brittany Araujo, Michal Elovitz, Jack Ludmir, Samuel Parry, Mary Peters, Grace Pien, Melissa Bickus, Steve N Caritis, Ashi R Daftary, Stephen P Emery, Francesca L Facco, Hyagriv N Simhan, Paul D Speer, George R Saade, Kelly Christensen, M Sean Esplin, Linda Meadows, Valerie Morby, Julie Postma, Robert M Silver, Melanie Williams, Ashish Aneja, Kelly Gibson, Jessica Pippen, Bonnie Rosolowski, Laniece Thomas, C Noel Bairey Merz, Natalie Bello, Ian Brower, Maria Marroquin, Jenna Maughan, Nathan Sela, Brandon Wanke, Eileen Yu, Casandra Almonte, Cande Ananth, Veronica Barcelona, Whitney Booker, Jeremy Chiu, Kirsten Cleary, Nathalie De La Cruz, Brandy Firman, Yessenia Gutierrez, Noora Haghighi, Carla Haro, Jennifer Haythe, Tal Korem, Eliza Miller, Belgica Peguero, Uma Reddy, Jeimy Rosado Feliz, Qi Yan, Carrie Kitto, Jennifer Nava, Amy Staples, Tetsuya Kawakita, Cathy Spong, Michael Honigberg, Erica-Jane Maro, Jessica Roby-Fout, Christina Scifres, Hannah Shockley, Ligia Vasquez-Hout, Haley Schmidt, Brittany Yeley, Anum Minhas, Victoria L Pemberton, Michael Twery, Jasmina Varagic, Philip Greenland, Bonnie J Kane, Kiarri Kershaw, Sadiya Khan, Minjee Kim, Elizabeth Rangel, Laura Seegmiller, Lynn M Yee, Alicia Lynch, McKenzie Jancsura, Courtney Lynch, Kartik Venkatesh, Jiqiang Wu, Carla Bann, Benjamin Carper, Emma Crenshaw, Brian Erman, Katie Fain, Carl Fisher, Sean Hanlon, Mallory Harris, Joey Hoellerich, Karen Kesler, Nick Kinsey, David Leblond, Derek Marsh, Taya McMillan, Rebecca B McNeil, Heather Meier, Janet Moore, Callie Riggs, Sridevi Sattaluri, Emily W Thomas, Vanessa Thorsten, Nathan Vandergrift, Roger Williams, Yii-Der Ida Chen, Phuong Linh L Huỳnh, Jin Kyung Kim, Nikka Shahrokni, Lizette Spiers, Amanda Thornton, Jesi Zavala, Caitlyn Hendrickson, Abbi Lane, Caroline Huang, Andrea Kozai, Lisa Levine, Jennifer Lewey, Meaghan McCabe, Maria Monterroso, Nadia Ngom, Keri Simonette, Saisahana Subburaj, Fatoumata Sy, Ainsley Bradbury, Allison Baxter, Lisa Bodnar, Samantha Bryan, Janet Catov, Christiana Ekekwe, Abigail Evans, Alisse Hauspurg, Lacey Heinsberg, Kimberly Huber, Michele Levine, Victoria Lopata, Christofer Price, Mitali Ray, Jill Tarr, Alexis Thrower, Julia Whiteleather, Nathan Blue, Maggie Cook, Danielle Heil, Torri Metz, Josh Oliver, Dexter Patterson, Karen Schliep, Lauren Theilen, Sharla Aldous, Stacey Breeze, Lindsey Carlson, Sandi Dellerman, Holly Evans, Bri Hobbs, Jessica Johnson, Jake Krong, Diana Magana, Catherine Meadows, Rachel Moore, Michael Nunley, Kristin Orton, Midra Pederson, Sara St Hilaire, Kailey Tingey, Nic Unsworth, Kristin Hansen, Claudia Korcarz, Bethany Barone Gibbs, Devin Lai, Sarah Modlin

Affiliations

¹ Division of Cardiology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
² Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
³ Department of Obstetrics and Gynecology, Ohio State University College of Medicine, Columbus.
⁴ Department of Obstetrics, Gynecology, and Reproductive Services, Magee-Womens Research Institute, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
⁵ Department of Cardiology, Barbra Streisand Women's Heart Center, Smidt Cedars-Sinai Heart Institute, Los Angeles, California.
⁶ Department of Obstetrics and Gynecology, University of California, Irvine.
⁷ Department of Applied Exercise Science, School of Kinesiology, University of Michigan, Ann Arbor.
⁸ Department of Obstetrics and Gynecology, Indiana University School of Medicine, Indianapolis.
⁹ Department of Obstetrics and Gynecology, University of Pennsylvania Perelman School of Medicine, Philadelphia.
¹⁰ RTI International, Research Triangle Park, North Carolina.
¹¹ Department of Neurology, Columbia University, New York, New York.
¹² Department of Obstetrics and Gynecology, University of Texas Medical Branch, Galveston, Galveston.
¹³ Department of Obstetrics and Gynecology, University of Utah, Salt Lake City.
¹⁴ Department of Obstetrics and Gynecology, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
¹⁵ Case Western Reserve University School of Medicine, Cleveland, Ohio.
¹⁶ Department of Obstetrics and Gynecology, Columbia University, New York, New York.
¹⁷ Associate Editor, JAMA Cardiology.

PMID: 40172904
PMCID: PMC11966469 (available on 2026-04-02)
DOI: 10.1001/jamacardio.2025.0325

No abstract available

Plain language summary

This cohort study examines the association of adverse pregnancy outcomes and N-terminal pro-brain natriuretic peptide levels years after delivery.

PubMed Disclaimer

Conflict of interest statement

Conflict of Interest Disclosures: None reported.

Cited by

Sailing Across Contraception, Pregnancy, and Breastfeeding: The Complex Journey of Women with Cardiomyopathies.
Carella MC, Santobuono VE, Grosso FM, Dicorato MM, Basile P, Dentamaro I, Naccarati ML, Santoro D, Monitillo F, Valecce R, Ruggieri R, Agea A, Pepe M, Pontone G, Vimercati A, Cicinelli E, Laforgia N, Resta N, Guaricci AI, Ciccone MM, Forleo C. Carella MC, et al. J Clin Med. 2025 Jul 14;14(14):4977. doi: 10.3390/jcm14144977. J Clin Med. 2025. PMID: 40725670 Free PMC article. Review.

References

1. Hansen AL, Søndergaard MM, Hlatky MA, et al. . Adverse pregnancy outcomes and incident heart failure in the Women’s Health Initiative. JAMA Netw Open. 2021;4(12):e2138071. doi:10.1001/jamanetworkopen.2021.38071 - DOI - PMC - PubMed
1. Countouris ME, Villanueva FS, Berlacher KL, Cavalcante JL, Parks WT, Catov JM. Association of hypertensive disorders of pregnancy with left ventricular remodeling later in life. J Am Coll Cardiol. 2021;77(8):1057-1068. doi:10.1016/j.jacc.2020.12.051 - DOI - PMC - PubMed
1. Haas DM, Parker CB, Wing DA, et al. . NuMoMb study. A description of the methods of the Nulliparous Pregnancy Outcomes Study: monitoring mothers-to-be (nuMoM2b). Am J Obstet Gynecol. 2015;212(4):539 e1-539 e24. doi:10.1016/j.ajog.2015.01.019 - DOI - PMC - PubMed
1. Haas DM, Ehrenthal DB, Koch MA, et al. ; National Heart, Lung, and Blood Institute nuMoM2b Heart Health Study Network . Pregnancy as a window to future cardiovascular health: design and implementation of the nuMoM2b Heart Health Study. Am J Epidemiol. 2016;183(6):519-530. doi:10.1093/aje/kwv309 - DOI - PMC - PubMed
1. Heidenreich PA, Bozkurt B, Aguilar D, et al. . 2022 AHA/ACC/HFSA guideline for the management of heart failure: a report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. J Am Coll Cardiol. 2022;79(17):e263-e421. doi:10.1016/j.jacc.2021.12.012 - DOI - PubMed

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[1] Hansen AL, Søndergaard MM, Hlatky MA, et al. . Adverse pregnancy outcomes and incident heart failure in the Women’s Health Initiative. JAMA Netw Open. 2021;4(12):e2138071. doi:10.1001/jamanetworkopen.2021.38071 - DOI - PMC - PubMed

[2] Hansen AL, Søndergaard MM, Hlatky MA, et al. . Adverse pregnancy outcomes and incident heart failure in the Women’s Health Initiative. JAMA Netw Open. 2021;4(12):e2138071. doi:10.1001/jamanetworkopen.2021.38071 - DOI - PMC - PubMed

[3] Countouris ME, Villanueva FS, Berlacher KL, Cavalcante JL, Parks WT, Catov JM. Association of hypertensive disorders of pregnancy with left ventricular remodeling later in life. J Am Coll Cardiol. 2021;77(8):1057-1068. doi:10.1016/j.jacc.2020.12.051 - DOI - PMC - PubMed

[4] Countouris ME, Villanueva FS, Berlacher KL, Cavalcante JL, Parks WT, Catov JM. Association of hypertensive disorders of pregnancy with left ventricular remodeling later in life. J Am Coll Cardiol. 2021;77(8):1057-1068. doi:10.1016/j.jacc.2020.12.051 - DOI - PMC - PubMed

[5] Haas DM, Parker CB, Wing DA, et al. . NuMoMb study. A description of the methods of the Nulliparous Pregnancy Outcomes Study: monitoring mothers-to-be (nuMoM2b). Am J Obstet Gynecol. 2015;212(4):539 e1-539 e24. doi:10.1016/j.ajog.2015.01.019 - DOI - PMC - PubMed

[6] Haas DM, Parker CB, Wing DA, et al. . NuMoMb study. A description of the methods of the Nulliparous Pregnancy Outcomes Study: monitoring mothers-to-be (nuMoM2b). Am J Obstet Gynecol. 2015;212(4):539 e1-539 e24. doi:10.1016/j.ajog.2015.01.019 - DOI - PMC - PubMed

[7] Haas DM, Ehrenthal DB, Koch MA, et al. ; National Heart, Lung, and Blood Institute nuMoM2b Heart Health Study Network . Pregnancy as a window to future cardiovascular health: design and implementation of the nuMoM2b Heart Health Study. Am J Epidemiol. 2016;183(6):519-530. doi:10.1093/aje/kwv309 - DOI - PMC - PubMed

[8] Haas DM, Ehrenthal DB, Koch MA, et al. ; National Heart, Lung, and Blood Institute nuMoM2b Heart Health Study Network . Pregnancy as a window to future cardiovascular health: design and implementation of the nuMoM2b Heart Health Study. Am J Epidemiol. 2016;183(6):519-530. doi:10.1093/aje/kwv309 - DOI - PMC - PubMed

[9] Heidenreich PA, Bozkurt B, Aguilar D, et al. . 2022 AHA/ACC/HFSA guideline for the management of heart failure: a report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. J Am Coll Cardiol. 2022;79(17):e263-e421. doi:10.1016/j.jacc.2021.12.012 - DOI - PubMed

[10] Heidenreich PA, Bozkurt B, Aguilar D, et al. . 2022 AHA/ACC/HFSA guideline for the management of heart failure: a report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. J Am Coll Cardiol. 2022;79(17):e263-e421. doi:10.1016/j.jacc.2021.12.012 - DOI - PubMed

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Adverse Pregnancy Outcomes and N-Terminal Pro-Brain Natriuretic Peptide Levels 2 to 7 Years After Delivery: The nuMoM2b Heart Health Study

Collaborators

Affiliations

Adverse Pregnancy Outcomes and N-Terminal Pro-Brain Natriuretic Peptide Levels 2 to 7 Years After Delivery: The nuMoM2b Heart Health Study

Authors

Collaborators

Affiliations

Plain language summary

Conflict of interest statement

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References

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Full Text Sources

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Conflict of interest statement

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References

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