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. 2025 Aug;282(8):4227-4236.
doi: 10.1007/s00405-025-09349-1. Epub 2025 Apr 4.

Balancing survival rates and quality-of-life outcomes after transoral laser microsurgery for locally advanced glottic cancer

Eduardo Breda  1 , Joana Marques  2 , Isabel Vasquez  3 , Eurico Monteiro  1
Affiliations

Balancing survival rates and quality-of-life outcomes after transoral laser microsurgery for locally advanced glottic cancer

Eduardo Breda et al. Eur Arch Otorhinolaryngol. 2025 Aug.

Abstract

Purpose: This study aims to analyze resectable T3-T4a glottic cancer patients treated with TOLM at a tertiary hospital, evaluating survival, function, and QoL in organ-preserved cases.

Methods: Patients with diagnosis of laryngeal glottic squamous cell carcinoma pT3-pT4a N < 3 M0 treated with primary curative intention TOLM from 2005 to 2021 were included. Statistical analysis was performed, including survival rates. Quality of life was evaluated using VHI-10, EORTC-QLQ-C30 and EORTC-QLQ-HN43.

Results: 82 patients were included in this study, predominantly male, with a mean age of 65.5 years old. Laryngeal preservation rate was 76.83%. 5-year overall survival was 68.3%, 5-year Disease Specific Survival was 80.9%, 5-year Local disease-free survival was 91.2%. Medium VHI-10 score was 9.20 (SD ± 5.90), with nearly two thirds (63.33%) having a normal score. On the QLQ-C30 questionnaire, five of the six functional scales were over 80. On the QLQ-HN43 all the scales (single and multi-item) scored less than 16.

Conclusion: TOLM achieved comparable survival rates to radical surgery and other organ-preserving methods for locally advanced glottic cancer, as well as good functional outcomes with minimal post-surgical symptoms and mild voice impairment.

Keywords: Advanced glottic cancer; Quality of life; Survival rates; Transoral laser microsurgery.

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Conflict of interest statement

Declarations. Conflict of interest: The authors declare no financial or non-financial interests that are directly or indirectly related to the work submitted for publication. Ethical approval: Present research was authorized by the Institutional Ethics Committee.

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References

    1. Bray F, Ferlay J, Soerjomataram I et al (2018) Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 68:394–424 - PubMed
    1. Timme DW, Jonnalagadda S, Patel R et al (2015) Treatment selection for T3/T4a laryngeal cancer: chemoradiation versus primary surgery. Ann Otol Rhinol Laryngol 124:845–851 - PubMed
    1. Danker H, Wollbruck D, Singer S et al (2010) Social withdrawal after laryngectomy. Eur Arch Otorhinolaryngol 267:593–600 - PubMed
    1. Piazza C, Paderno A, Sjogren EV et al (2021) Salvage carbon dioxide transoral laser microsurgery for laryngeal cancer after (chemo)radiotherapy: a European Laryngological Society consensus statement. Eur Arch Otorhinolaryngol 278:4373–4381 - PubMed - PMC
    1. Steiner W, Ambrosch P (2000) Endoscopic laser surgery of the upper aerodigestive tract with special emphasis on cancer surgery. In: York TSN (ed) Endoscopic laser surgery of the upper aerodigestive tract with special emphasis on cancer surgery. Thieme, New York

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