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. 2025 Jun;41(6):456-458.
doi: 10.1016/j.tig.2025.03.002. Epub 2025 Apr 2.

DNA lesions piece together impossible trees

Claudia Arnedo-Pac  1 , Sarah J Aitken  2
Affiliations
Free article

DNA lesions piece together impossible trees

Claudia Arnedo-Pac et al. Trends Genet. 2025 Jun.
Free article

Abstract

DNA lesions can persist through multiple cell cycles, resulting in mutational strand asymmetry, multiallelic variation, and somatic mosaicism. But for how long do these lesions persist? Recent work from Spencer Chapman et al. shows that they can last for months to years, even arising from endogenous exposures in utero.

Keywords: DNA damage; DNA lesion; lesion segregation; multiallelism; mutagenesis; phylogenetics.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

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