. 2025 Apr;28(4):891-901.

doi: 10.1038/s41593-025-01907-4. Epub 2025 Apr 3.

Human lifespan changes in the brain's functional connectome

Lianglong Sun^{1

2

3}, Tengda Zhao^{1

2

3}, Xinyuan Liang^{1

2

3}, Mingrui Xia^{1

2

3}, Qiongling Li^{1

2

3}, Xuhong Liao⁴, Gaolang Gong^{1

2

3

5}, Qian Wang^{1

2

3}, Chenxuan Pang^{1

2

3}, Qian Yu^{1

2

3}, Yanchao Bi^{1

2

3

5}, Pindong Chen⁶, Rui Chen¹, Yuan Chen⁷, Taolin Chen^{8

9}, Jingliang Cheng⁷, Yuqi Cheng¹⁰, Zaixu Cui⁵, Zhengjia Dai^{1

2

3}, Yao Deng¹, Yuyin Ding¹, Qi Dong¹, Dingna Duan^{1

2

3}, Jia-Hong Gao^{11

12

13}, Qiyong Gong^{8

9}, Ying Han¹⁴, Zaizhu Han^{1

3}, Chu-Chung Huang¹⁵, Ruiwang Huang^{1

3}, Ran Huo¹⁶, Lingjiang Li^{17

18}, Ching-Po Lin^{19

20

21}, Qixiang Lin^{1

2

3}, Bangshan Liu^{17

18}, Chao Liu^{1

3}, Ningyu Liu¹, Ying Liu¹⁶, Yong Liu²², Jing Lu¹, Leilei Ma¹, Weiwei Men^{11

12}, Shaozheng Qin^{1

2

3

5}, Jiang Qiu^{23

24}, Shijun Qiu²⁵, Tianmei Si²⁶, Shuping Tan²⁷, Yanqing Tang²⁸, Sha Tao¹, Dawei Wang²⁹, Fei Wang²⁸, Jiali Wang¹, Pan Wang³⁰, Xiaoqin Wang^{23

24}, Yanpei Wang¹, Dongtao Wei^{23

24}, Yankun Wu²⁶, Peng Xie^{31

32}, Xiufeng Xu¹⁰, Yuehua Xu^{1

2

3}, Zhilei Xu^{1

2

3}, Liyuan Yang^{1

2

3}, Huishu Yuan¹⁶, Zilong Zeng^{1

2

3}, Haibo Zhang¹, Xi Zhang³³, Gai Zhao¹, Yanting Zheng²⁵, Suyu Zhong²²; Alzheimer’s Disease Neuroimaging Initiative; DIDA-MDD Working Group; MCADI; Yong He^{34

35

36

37}

Collaborators, Affiliations

Collaborators

Michael Weiner, Paul Aisen, Ronald Petersen, Clifford R Jack Jr, William Jagust, John Q Trojanowki, Arthur W Toga, Laurel Beckett, Robert C Green, Andrew J Saykin, John Morris, Leslie M Shaw, Enchi Liu, Tom Montine, Ronald G Thomas, Michael Donohue, Sarah Walter, Devon Gessert, Tamie Sather, Gus Jiminez, Danielle Harvey, Matthew Bernstein, Nick Fox, Paul Thompson, Norbert Schuff, Charles DeCArli, Bret Borowski, Jeff Gunter, Matt Senjem, Prashanthi Vemuri, David Jones, Kejal Kantarci, Chad Ward, Robert A Koeppe, Norm Foster, Eric M Reiman, Kewei Chen, Chet Mathis, Susan Landau, Nigel J Cairns, Erin Householder, Lisa Taylor Reinwald, Virginia Lee, Magdalena Korecka, Michal Figurski, Karen Crawford, Scott Neu, Tatiana M Foroud, Steven Potkin, Li Shen, Faber Kelley, Sungeun Kim, Kwangsik Nho, Zaven Kachaturian, Richard Frank, Peter J Snyder, Susan Molchan, Jeffrey Kaye, Joseph Quinn, Betty Lind, Raina Carter, Sara Dolen, Lon S Schneider, Sonia Pawluczyk, Mauricio Beccera, Liberty Teodoro, Bryan M Spann, James Brewer, Helen Vanderswag, Adam Fleisher, Judith L Heidebrink, Joanne L Lord, Sara S Mason, Colleen S Albers, David Knopman, Kris Johnson, Rachelle S Doody, Javier Villanueva Meyer, Munir Chowdhury, Susan Rountree, Mimi Dang, Yaakov Stern, Lawrence S Honig, Karen L Bell, Beau Ances, John C Morris, Maria Carroll, Sue Leon, Mark A Mintun, Stacy Schneider, Angela Oliver, Randall Griffith, David Clark, David Geldmacher, John Brockington, Erik Roberson, Hillel Grossman, Effie Mitsis, Leyla deToledo-Morrell, Raj C Shah, Ranjan Duara, Daniel Varon, Maria T Greig, Peggy Roberts, Marilyn Albert, Chiadi Onyike, Daniel D'Agostino 2nd, Stephanie Kielb, James E Galvin, Dana M Pogorelec, Brittany Cerbone, Christina A Michel, Henry Rusinek, Mony J de Leon, Lidia Glodzik, Susan De Santi, P Murali Doraiswamy, Jeffrey R Petrella, Terence Z Wong, Steven E Arnold, Jason H Karlawish, David Wolk, Charles D Smith, Greg Jicha, Peter Hardy, Partha Sinha, Elizabeth Oates, Gary Conrad, Oscar L Lopez, MaryAnn Oakley, Donna M Simpson, Anton P Porsteinsson, Bonnie S Goldstein, Kim Martin, Kelly M Makino, M Saleem Ismail, Connie Brand, Ruth A Mulnard, Gaby Thai, Catherine McAdams Ortiz, Kyle Womack, Dana Mathews, Mary Quiceno, Ramon Diaz Arrastia, Richard King, Myron Weiner, Kristen Martin Cook, Michael DeVous, Allan I Levey, James J Lah, Janet S Cellar, Jeffrey M Burns, Heather S Anderson, Russell H Swerdlow, Liana Apostolova, Kathleen Tingus, Ellen Woo, Daniel H S Silverman, Po H Lu, George Bartzokis, Neill R Graff Radford, Francine Parfitt, Tracy Kendall, Heather Johnson, Martin R Farlow, Ann Marie Hake, Brandy R Matthews, Scott Herring, Cynthia Hunt, Christopher H van Dyck, Richard E Carson, Martha G MacAvoy, Howard Chertkow, Howard Bergman, Chris Hosein, Sandra Black, Bojana Stefanovic, Curtis Caldwell, Ging Yuek Robin Hsiung, Howard Feldman, Benita Mudge, Michele Assaly Past, Andrew Kertesz, John Rogers, Dick Trost, Charles Bernick, Donna Munic, Diana Kerwin, Marek Marsel Mesulam, Kristine Lipowski, Chuang Kuo Wu, Nancy Johnson, Carl Sadowsky, Walter Martinez, Teresa Villena, Raymond Scott Turner, Kathleen Johnson, Brigid Reynolds, Reisa A Sperling, Keith A Johnson, Gad Marshall, Meghan Frey, Jerome Yesavage, Joy L Taylor, Barton Lane, Allyson Rosen, Jared Tinklenberg, Marwan N Sabbagh, Christine M Belden, Sandra A Jacobson, Sherye A Sirrel, Neil Kowall, Ronald Killiany, Andrew E Budson, Alexander Norbash, Patricia Lynn Johnson, Thomas O Obisesan, Saba Wolday, Joanne Allard, Alan Lerner, Paula Ogrocki, Leon Hudson, Evan Fletcher, Owen Carmichael, John Olichney, Charles DeCarli, Smita Kittur, Michael Borrie, T Y Lee, Rob Bartha, Sterling Johnson, Sanjay Asthana, Cynthia M Carlsson, Steven G Potkin, Adrian Preda, Dana Nguyen, Pierre Tariot, Stephanie Reeder, Vernice Bates, Horacio Capote, Michelle Rainka, Douglas W Scharre, Maria Kataki, Anahita Adeli, Earl A Zimmerman, Dzintra Celmins, Alice D Brown, Godfrey D Pearlson, Karen Blank, Karen Anderson, Robert B Santulli, Tamar J Kitzmiller, Eben S Schwartz, Kaycee M Sink, Jeff D Williamson, Pradeep Garg, Franklin Watkins, Brian R Ott, Henry Querfurth, Geoffrey Tremont, Stephen Salloway, Paul Malloy, Stephen Correia, Howard J Rosen, Bruce L Miller, Jacobo Mintzer, Kenneth Spicer, David Bachman, Elizabether Finger, Stephen Pasternak, Irina Rachinsky, Dick Drost, Nunzio Pomara, Raymundo Hernando, Antero Sarrael, Susan K Schultz, Laura L Boles Ponto, Hyungsub Shim, Karen Elizabeth Smith, Norman Relkin, Gloria Chaing, Lisa Raudin, Amanda Smith, Kristin Fargher, Balebail Ashok Raj, Yuying Zhou

Affiliations

¹ State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China.
² Beijing Key Laboratory of Brain Imaging and Connectomics, Beijing Normal University, Beijing, China.
³ IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, China.
⁴ School of Systems Science, Beijing Normal University, Beijing, China.
⁵ Chinese Institute for Brain Research, Beijing, China.
⁶ Brainnetome Center & National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing, China.
⁷ Department of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
⁸ Department of Radiology, Huaxi MR Research Center (HMRRC), Institute of Radiology, Functional and Molecular Imaging Key Laboratory of Sichuan Province, West China Hospital of Sichuan University, Chengdu, China.
⁹ Xiamen Key Laboratory of Psychoradiology and Neuromodulation, Department of Radiology, West China Xiamen Hospital of Sichuan University, Xiamen, China.
¹⁰ Department of Psychiatry, First Affiliated Hospital of Kunming Medical University, Kunming, China.
¹¹ Center for MRI Research, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China.
¹² Beijing City Key Laboratory for Medical Physics and Engineering, Institute of Heavy Ion Physics, School of Physics, Peking University, Beijing, China.
¹³ IDG/McGovern Institute for Brain Research, Peking University, Beijing, China.
¹⁴ Department of Neurology, Xuanwu Hospital of Capital Medical University, Beijing, China.
¹⁵ Key Laboratory of Brain Functional Genomics (Ministry of Education), Affiliated Mental Health Center (ECNU), School of Psychology and Cognitive Science, East China Normal University, Shanghai, China.
¹⁶ Department of Radiology, Peking University Third Hospital, Beijing, China.
¹⁷ Department of Psychiatry, and National Clinical Research Center for Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha, China.
¹⁸ Mental Health Institute of Central South University, China National Technology Institute on Mental Disorders, Hunan Technology Institute of Psychiatry, Hunan Key Laboratory of Psychiatry and Mental Health, Hunan Medical Center for Mental Health, Changsha, China.
¹⁹ Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, China.
²⁰ Institute of Neuroscience, National Yang Ming Chiao Tung University, Taipei, China.
²¹ Department of Education and Research, Taipei City Hospital, Taipei, China.
²² Center for Artificial Intelligence in Medical Imaging, School of Artificial Intelligence, Beijing University of Posts and Telecommunications, Beijing, China.
²³ Key Laboratory of Cognition and Personality (SWU), Ministry of Education, Chongqing, China.
²⁴ Department of Psychology, Southwest University, Chongqing, China.
²⁵ Department of Radiology, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China.
²⁶ Peking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Peking University, Beijing, China.
²⁷ Beijing Huilongguan Hospital, Peking University Huilongguan Clinical Medical School, Beijing, China.
²⁸ Department of Psychiatry, The First Affiliated Hospital of China Medical University, Shenyang, China.
²⁹ Department of Radiology, Qilu Hospital of Shandong University, Ji'nan, China.
³⁰ Department of Neurology, Tianjin Huanhu Hospital, Tianjin University, Tianjin, China.
³¹ Chongqing Key Laboratory of Neurobiology, Chongqing, China.
³² Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
³³ Department of Neurology, the Second Medical Centre, National Clinical Research Centre for Geriatric Diseases, Chinese PLA General Hospital, Beijing, China.
³⁴ State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China. yong.he@bnu.edu.cn.
³⁵ Beijing Key Laboratory of Brain Imaging and Connectomics, Beijing Normal University, Beijing, China. yong.he@bnu.edu.cn.
³⁶ IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, China. yong.he@bnu.edu.cn.
³⁷ Chinese Institute for Brain Research, Beijing, China. yong.he@bnu.edu.cn.

PMID: 40181189
DOI: 10.1038/s41593-025-01907-4

Human lifespan changes in the brain's functional connectome

Lianglong Sun et al. Nat Neurosci. 2025 Apr.

. 2025 Apr;28(4):891-901.

doi: 10.1038/s41593-025-01907-4. Epub 2025 Apr 3.

Authors

Collaborators

Michael Weiner, Paul Aisen, Ronald Petersen, Clifford R Jack Jr, William Jagust, John Q Trojanowki, Arthur W Toga, Laurel Beckett, Robert C Green, Andrew J Saykin, John Morris, Leslie M Shaw, Enchi Liu, Tom Montine, Ronald G Thomas, Michael Donohue, Sarah Walter, Devon Gessert, Tamie Sather, Gus Jiminez, Danielle Harvey, Matthew Bernstein, Nick Fox, Paul Thompson, Norbert Schuff, Charles DeCArli, Bret Borowski, Jeff Gunter, Matt Senjem, Prashanthi Vemuri, David Jones, Kejal Kantarci, Chad Ward, Robert A Koeppe, Norm Foster, Eric M Reiman, Kewei Chen, Chet Mathis, Susan Landau, Nigel J Cairns, Erin Householder, Lisa Taylor Reinwald, Virginia Lee, Magdalena Korecka, Michal Figurski, Karen Crawford, Scott Neu, Tatiana M Foroud, Steven Potkin, Li Shen, Faber Kelley, Sungeun Kim, Kwangsik Nho, Zaven Kachaturian, Richard Frank, Peter J Snyder, Susan Molchan, Jeffrey Kaye, Joseph Quinn, Betty Lind, Raina Carter, Sara Dolen, Lon S Schneider, Sonia Pawluczyk, Mauricio Beccera, Liberty Teodoro, Bryan M Spann, James Brewer, Helen Vanderswag, Adam Fleisher, Judith L Heidebrink, Joanne L Lord, Sara S Mason, Colleen S Albers, David Knopman, Kris Johnson, Rachelle S Doody, Javier Villanueva Meyer, Munir Chowdhury, Susan Rountree, Mimi Dang, Yaakov Stern, Lawrence S Honig, Karen L Bell, Beau Ances, John C Morris, Maria Carroll, Sue Leon, Mark A Mintun, Stacy Schneider, Angela Oliver, Randall Griffith, David Clark, David Geldmacher, John Brockington, Erik Roberson, Hillel Grossman, Effie Mitsis, Leyla deToledo-Morrell, Raj C Shah, Ranjan Duara, Daniel Varon, Maria T Greig, Peggy Roberts, Marilyn Albert, Chiadi Onyike, Daniel D'Agostino 2nd, Stephanie Kielb, James E Galvin, Dana M Pogorelec, Brittany Cerbone, Christina A Michel, Henry Rusinek, Mony J de Leon, Lidia Glodzik, Susan De Santi, P Murali Doraiswamy, Jeffrey R Petrella, Terence Z Wong, Steven E Arnold, Jason H Karlawish, David Wolk, Charles D Smith, Greg Jicha, Peter Hardy, Partha Sinha, Elizabeth Oates, Gary Conrad, Oscar L Lopez, MaryAnn Oakley, Donna M Simpson, Anton P Porsteinsson, Bonnie S Goldstein, Kim Martin, Kelly M Makino, M Saleem Ismail, Connie Brand, Ruth A Mulnard, Gaby Thai, Catherine McAdams Ortiz, Kyle Womack, Dana Mathews, Mary Quiceno, Ramon Diaz Arrastia, Richard King, Myron Weiner, Kristen Martin Cook, Michael DeVous, Allan I Levey, James J Lah, Janet S Cellar, Jeffrey M Burns, Heather S Anderson, Russell H Swerdlow, Liana Apostolova, Kathleen Tingus, Ellen Woo, Daniel H S Silverman, Po H Lu, George Bartzokis, Neill R Graff Radford, Francine Parfitt, Tracy Kendall, Heather Johnson, Martin R Farlow, Ann Marie Hake, Brandy R Matthews, Scott Herring, Cynthia Hunt, Christopher H van Dyck, Richard E Carson, Martha G MacAvoy, Howard Chertkow, Howard Bergman, Chris Hosein, Sandra Black, Bojana Stefanovic, Curtis Caldwell, Ging Yuek Robin Hsiung, Howard Feldman, Benita Mudge, Michele Assaly Past, Andrew Kertesz, John Rogers, Dick Trost, Charles Bernick, Donna Munic, Diana Kerwin, Marek Marsel Mesulam, Kristine Lipowski, Chuang Kuo Wu, Nancy Johnson, Carl Sadowsky, Walter Martinez, Teresa Villena, Raymond Scott Turner, Kathleen Johnson, Brigid Reynolds, Reisa A Sperling, Keith A Johnson, Gad Marshall, Meghan Frey, Jerome Yesavage, Joy L Taylor, Barton Lane, Allyson Rosen, Jared Tinklenberg, Marwan N Sabbagh, Christine M Belden, Sandra A Jacobson, Sherye A Sirrel, Neil Kowall, Ronald Killiany, Andrew E Budson, Alexander Norbash, Patricia Lynn Johnson, Thomas O Obisesan, Saba Wolday, Joanne Allard, Alan Lerner, Paula Ogrocki, Leon Hudson, Evan Fletcher, Owen Carmichael, John Olichney, Charles DeCarli, Smita Kittur, Michael Borrie, T Y Lee, Rob Bartha, Sterling Johnson, Sanjay Asthana, Cynthia M Carlsson, Steven G Potkin, Adrian Preda, Dana Nguyen, Pierre Tariot, Stephanie Reeder, Vernice Bates, Horacio Capote, Michelle Rainka, Douglas W Scharre, Maria Kataki, Anahita Adeli, Earl A Zimmerman, Dzintra Celmins, Alice D Brown, Godfrey D Pearlson, Karen Blank, Karen Anderson, Robert B Santulli, Tamar J Kitzmiller, Eben S Schwartz, Kaycee M Sink, Jeff D Williamson, Pradeep Garg, Franklin Watkins, Brian R Ott, Henry Querfurth, Geoffrey Tremont, Stephen Salloway, Paul Malloy, Stephen Correia, Howard J Rosen, Bruce L Miller, Jacobo Mintzer, Kenneth Spicer, David Bachman, Elizabether Finger, Stephen Pasternak, Irina Rachinsky, Dick Drost, Nunzio Pomara, Raymundo Hernando, Antero Sarrael, Susan K Schultz, Laura L Boles Ponto, Hyungsub Shim, Karen Elizabeth Smith, Norman Relkin, Gloria Chaing, Lisa Raudin, Amanda Smith, Kristin Fargher, Balebail Ashok Raj, Yuying Zhou

Affiliations

¹ State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China.
² Beijing Key Laboratory of Brain Imaging and Connectomics, Beijing Normal University, Beijing, China.
³ IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, China.
⁴ School of Systems Science, Beijing Normal University, Beijing, China.
⁵ Chinese Institute for Brain Research, Beijing, China.
⁶ Brainnetome Center & National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing, China.
⁷ Department of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
⁸ Department of Radiology, Huaxi MR Research Center (HMRRC), Institute of Radiology, Functional and Molecular Imaging Key Laboratory of Sichuan Province, West China Hospital of Sichuan University, Chengdu, China.
⁹ Xiamen Key Laboratory of Psychoradiology and Neuromodulation, Department of Radiology, West China Xiamen Hospital of Sichuan University, Xiamen, China.
¹⁰ Department of Psychiatry, First Affiliated Hospital of Kunming Medical University, Kunming, China.
¹¹ Center for MRI Research, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China.
¹² Beijing City Key Laboratory for Medical Physics and Engineering, Institute of Heavy Ion Physics, School of Physics, Peking University, Beijing, China.
¹³ IDG/McGovern Institute for Brain Research, Peking University, Beijing, China.
¹⁴ Department of Neurology, Xuanwu Hospital of Capital Medical University, Beijing, China.
¹⁵ Key Laboratory of Brain Functional Genomics (Ministry of Education), Affiliated Mental Health Center (ECNU), School of Psychology and Cognitive Science, East China Normal University, Shanghai, China.
¹⁶ Department of Radiology, Peking University Third Hospital, Beijing, China.
¹⁷ Department of Psychiatry, and National Clinical Research Center for Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha, China.
¹⁸ Mental Health Institute of Central South University, China National Technology Institute on Mental Disorders, Hunan Technology Institute of Psychiatry, Hunan Key Laboratory of Psychiatry and Mental Health, Hunan Medical Center for Mental Health, Changsha, China.
¹⁹ Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, China.
²⁰ Institute of Neuroscience, National Yang Ming Chiao Tung University, Taipei, China.
²¹ Department of Education and Research, Taipei City Hospital, Taipei, China.
²² Center for Artificial Intelligence in Medical Imaging, School of Artificial Intelligence, Beijing University of Posts and Telecommunications, Beijing, China.
²³ Key Laboratory of Cognition and Personality (SWU), Ministry of Education, Chongqing, China.
²⁴ Department of Psychology, Southwest University, Chongqing, China.
²⁵ Department of Radiology, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China.
²⁶ Peking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Peking University, Beijing, China.
²⁷ Beijing Huilongguan Hospital, Peking University Huilongguan Clinical Medical School, Beijing, China.
²⁸ Department of Psychiatry, The First Affiliated Hospital of China Medical University, Shenyang, China.
²⁹ Department of Radiology, Qilu Hospital of Shandong University, Ji'nan, China.
³⁰ Department of Neurology, Tianjin Huanhu Hospital, Tianjin University, Tianjin, China.
³¹ Chongqing Key Laboratory of Neurobiology, Chongqing, China.
³² Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
³³ Department of Neurology, the Second Medical Centre, National Clinical Research Centre for Geriatric Diseases, Chinese PLA General Hospital, Beijing, China.
³⁴ State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China. yong.he@bnu.edu.cn.
³⁵ Beijing Key Laboratory of Brain Imaging and Connectomics, Beijing Normal University, Beijing, China. yong.he@bnu.edu.cn.
³⁶ IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, China. yong.he@bnu.edu.cn.
³⁷ Chinese Institute for Brain Research, Beijing, China. yong.he@bnu.edu.cn.

PMID: 40181189
DOI: 10.1038/s41593-025-01907-4

Abstract

Functional connectivity of the human brain changes through life. Here, we assemble task-free functional and structural magnetic resonance imaging data from 33,250 individuals at 32 weeks of postmenstrual age to 80 years from 132 global sites. We report critical inflection points in the nonlinear growth curves of the global mean and variance of the connectome, peaking in the late fourth and late third decades of life, respectively. After constructing a fine-grained, lifespan-wide suite of system-level brain atlases, we show distinct maturation timelines for functional segregation within different systems. Lifespan growth of regional connectivity is organized along a spatiotemporal cortical axis, transitioning from primary sensorimotor regions to higher-order association regions. These findings elucidate the lifespan evolution of the functional connectome and can serve as a normative reference for quantifying individual variation in development, aging and neuropsychiatric disorders.

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Conflict of interest statement

Competing interests: The authors declare no competing interests.

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References

1. Biswal, B., Yetkin, F. Z., Haughton, V. M. & Hyde, J. S. Functional connectivity in the motor cortex of resting human brain using echo-planar MRI. Magn. Reson. Med. 34, 537–541 (1995). - PubMed - DOI
1. Sporns, O., Tononi, G. & Kotter, R. The human connectome: a structural description of the human brain. PLoS Comput Biol. 1, e42 (2005). - PubMed - PMC - DOI
1. Smith, S. M. et al. Functional connectomics from resting-state fMRI. Trends Cogn. Sci. 17, 666–682 (2013). - PubMed - PMC - DOI
1. Cao, M., Huang, H. & He, Y. Developmental connectomics from infancy through early childhood. Trends Neurosci. 40, 494–506 (2017). - PubMed - PMC - DOI
1. Zuo, X. N. et al. Human connectomics across the life span. Trends Cogn. Sci. 21, 32–45 (2017). - PubMed - DOI

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Human lifespan changes in the brain's functional connectome

Collaborators

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Human lifespan changes in the brain's functional connectome

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Abstract

Conflict of interest statement

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