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. 1985 Apr 23;111(1):129-32.
doi: 10.1016/0014-2999(85)90122-0.

Angiotensin II enhances calcium exchanges in isolated rat aorta

R Schleiffer, A Gairard

Angiotensin II enhances calcium exchanges in isolated rat aorta

R Schleiffer et al. Eur J Pharmacol. .

Abstract

The effect of angiotensin II (AII) on calcium exchanges in isolated rat aorta was investigated using the 45Ca lanthanum technique. AII induced a rapid (10 s) and long-lasting (120 min) increase of calcium uptake and enhanced calcium release for a short period. AII-stimulated calcium uptake was antagonized by saralasin and verapamil but not by indomethacin. These data indicate that AII increases rat aortic calcium exchanges via receptor-operated and voltage-dependent calcium channels.

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