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Review
. 2025 Aug;100(4):1698-1715.
doi: 10.1111/brv.70020. Epub 2025 Apr 3.

Unravelling the regulatory network behind chitin degradation in Serratia marcescens

Wouter Demeester  1 , Brecht De Paepe  1 , Chiara Guidi  1 , Marjan De Mey  1
Affiliations
Review

Unravelling the regulatory network behind chitin degradation in Serratia marcescens

Wouter Demeester et al. Biol Rev Camb Philos Soc. 2025 Aug.

Abstract

Chitin degradation plays a crucial role in bacterial nutrient recycling and is performed by specialised, chitinolytic microorganisms such as Serratia marcescens, which is known to excel at this biological process. While its chitinolytic enzymes have been studied in detail, the underlying regulatory systems that allow such proficiency at chitin utilisation remain elusive. This review addresses different aspects of chitin degradation by Serratia marcescens. Together with a summary of the necessary enzymes and transport systems for extracellular chitin degradation, we focus on the strategies employed by Serratia marcescens for optimal use of different carbon sources in the presence of chitin. A complex, multi-layered, regulatory network results in 'bet-hedging', involving the formation of phenotypically bistable populations that facilitate a rapid transition towards chitin degradation when required. For the first time, a model of chitin degradation by Serratia marcescens is proposed, and aspects that currently remain elusive are highlighted. Hence, this review provides the basis for further investigations to reach a holistic understanding of this intriguing and important biological system.

Keywords: ChiR; Serratia marcescens; bet‐hedging; chitin degradation; regulatory networks.

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References

REFERENCES

    1. Abo‐Amer, A. E. (2011). Biodegradation of diazinon by Serratia marcescens DI101 and its use in bioremediation of contaminated environment. Journal of Microbiology and Biotechnology 21(1), 71–80.
    1. Acar, M., Becskei, A. & Van Oudenaarden, A. (2005). Enhancement of cellular memory by reducing stochastic transitions. Nature 435(7039), 228–232.
    1. Acar, M., Mettetal, J. T. & Van Oudenaarden, A. (2008). Stochastic switching as a survival strategy in fluctuating environments. Nature Genetics 40(4), 471–475.
    1. Ackermann, M. (2015). A functional perspective on phenotypic heterogeneity in microorganisms. Nature Reviews Microbiology 13(8), 497–508.
    1. Amin, N. & Peterkofsky, A. (1995). A dual mechanism for regulating cAMP levels in Escherichia coli. Journal of Biological Chemistry 270(20), 11803–11805.

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