Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2025 Apr 3;44(1):106.
doi: 10.1186/s41043-025-00846-x.

The association between magnesium depletion score (MDS) and overactive bladder (OAB) among the U.S. population

Hongyang Gong  1   2 , Weimin Zhao  3 , Seok Choi  2 , Shaoqun Huang  4
Affiliations

The association between magnesium depletion score (MDS) and overactive bladder (OAB) among the U.S. population

Hongyang Gong et al. J Health Popul Nutr. .

Abstract

Objective: This study aimed to assess the relationship between magnesium depletion score (MDS) and overactive bladder (OAB) prevalence.

Methods: This study utilized data from the National Health and Nutrition Examination Survey (NHANES) from 2005 to 2018. Multivariate logistic regression was employed to investigate the association between MDS and OAB. Restricted cubic spline (RCS) analysis explored the linear or non-linear relationship between MDS and OAB. Interaction analyses were conducted on subgroups to validate the findings.

Results: There was a significant positive association between MDS and OAB. After adjusting for covariates, with each unit increase in MDS, there was an 11% increase in the prevalence of infertility (P < 0.001). In addition, the incidence of OAB was significantly increased in the higher MDS group compared to the low MDS group (MDS = 0) (P for trend < 0.001). The dose-response curve indicated a linear association between MDS and OAB, with higher MDS associated with higher OAB.

Conclusion: The results of this study show a strong positive correlation between MDS and the prevalence of OAB. These findings suggest that monitoring and managing magnesium status may be a potential strategy for reducing the risk of OAB.

Keywords: Association; Magnesium depletion score; NHANES; Overactive bladder; U.S. Population.

PubMed Disclaimer

Conflict of interest statement

Declarations. Ethics approval and consent to participate: The data survey conducted by NHANES has been approved by the NCHS Research Ethics Review Board (ERB). All information from the NHANES program is available and free for the public, so an individual investigator was not necessary to obtain approval from the institution’s internal ethics review board. Consent for publication: Not Applicable. Competing interests: The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
A flow diagram of eligible participant selection in the national health and nutrition examination slurvey
Fig. 2
Fig. 2
Dose-response relationships between MDS and OAB. OR (solid lines) and 95% confidence levels (shaded areas) were adjusted for age, gender, education level, marital, PIR, race, obesity, smoking, drinking, hypertension, and diabetes
Fig. 3
Fig. 3
Subgroup analysis between MDS and OAB. ORs were calculated as each unit increased in MDS. Analyses were adjusted for age, gender, education level, marital, PIR, race, obesity, smoking, drinking, hypertension, and diabetes
See this image and copyright information in PMC

References

    1. Henderson E, Drake M. Overactive bladder. Maturitas. 2010;66:257–62. - PubMed
    1. Leron E, Weintraub AY, Mastrolia SA, Schwarzman P. Overactive bladder syndrome: evaluation and management. Curr Urol. 2018;11:117–25. - PMC - PubMed
    1. Andersson K-E, Arner A. Urinary bladder contraction and relaxation: physiology and pathophysiology. Physiol Rev. 2004;84:935–86. - PubMed
    1. de Groat WC. A neurologic basis for the overactive bladder. Urology. 1997;50:36–52. discussion 53–56. - PubMed
    1. Brading A. Spontaneous activity of lower urinary tract smooth muscles: correlation between ion channels and tissue function. J Physiol. 2006;570:13–22. - PMC - PubMed