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Meta-Analysis
. 2025 Apr 4;410(1):120.
doi: 10.1007/s00423-025-03691-y.

The effect of pre-operative MRI on the in-breast tumor recurrence rate of patients with breast cancer: a meta-analysis

Mahdieh Khoshzaban Banisi #  1 , Hani Ghadri #  2 , Behnaz Soltani #  3 , Amirali Farshid  4 , Bahar Behnam  1 , Amir Abbas Rhouholamini  1 , Amirhossein Mohammadi  1 , Seyedeh Fatemeh Hamzavi  1 , Ashkan Azizi  5 , Niloofar Deravi  1 , Masoud Noroozi  6 , Amin Magsudy  7 , Sina Seyedipour  8 , Shima Behzad  9 , Yaser Khakpour  10
Affiliations
Meta-Analysis

The effect of pre-operative MRI on the in-breast tumor recurrence rate of patients with breast cancer: a meta-analysis

Mahdieh Khoshzaban Banisi et al. Langenbecks Arch Surg. .

Abstract

Purpose: The impact of preoperative MRI on breast cancer recurrence and long-term outcomes remains undefined. Therefore, this study aims at determining the influence of preoperative MRI on in-breast tumor recurrence rates in cases of surgical treatment for breast cancer.

Methods: A systematic review and meta-analysis were performed. Literature searches of PubMed, Scopus, and Google Scholar were conducted for studies up to February 2024. Two authors assessed the quality of the eligible studies and extracted their data.

Results: The meta-analysis included 14 studies (2 RCTs, 12 cohort studies) with 12,889 patients with 5,451 undergoing preoperative MRI. Pooled hazard ratio for in-breast tumor recurrence was 0.95, using fixed effects and 0.94 using random effects models with 95% confidence intervals of 0.80-1.14 and 0.77-1.14, respectively. A trend towards lower recurrence rates in the MRI group was seen, but the reduction was not statistically significant.

Conclusion: This meta-analysis found no significant reduction in in-breast tumor recurrence rates associated with preoperative MRI use in breast cancer patients, consistent with previous findings.

Keywords: Breast neoplasms; Magnetic resonance imaging; Meta-analysis; Preoperative evaluation; Recurrence.

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Conflict of interest statement

Declarations. Ethics approval and consent to participate: Not applicable. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
PRISMA flow diagram
Fig. 2
Fig. 2
Forest plot of the effect of pre-operative MRI on the in-breast tumor recurrence rate of patients with breast cancer. Abbreviation: CI, confidence interval, HR: hazard ratio, TE: treatment effect, seTE: standard error of treatment effect
Fig. 3
Fig. 3
Sensitivity Analysis of the effect of pre-operative MRI on the in-breast tumor recurrence rate of patients with breast cancer. Abbreviation: CI, confidence interval, HR: hazard ratio, MRI: Magnetic resonance imaging
Fig. 4
Fig. 4
Funnel plot for publication bias assessment
See this image and copyright information in PMC

References

    1. Pittinger TP, Maronian NC, Poulter CA, Peacock JL (1994) Importance of margin status in outcome of breast-conserving surgery for carcinoma. Surgery. 116(4):605-8 discussion 8–9 - PubMed
    1. Tartter PI, Kaplan J, Bleiweiss I, Gajdos C, Kong A, Ahmed S et al (2000) Lumpectomy margins, reexcision, and local recurrence of breast cancer. Am J Surg 179(2):81–85. 10.1016/s0002-9610(00)00272-5 - PubMed
    1. Houssami N, Macaskill P, Marinovich ML, Dixon JM, Irwig L, Brennan ME et al (2010) Meta-analysis of the impact of surgical margins on local recurrence in women with early-stage invasive breast cancer treated with breast-conserving therapy. Eur J Cancer 46(18):3219–3232. 10.1016/j.ejca.2010.07.043 - PubMed
    1. Mann RM, Kuhl CK, Kinkel K, Boetes C (2008) Breast MRI: guidelines from the European society of breast imaging. Eur Radiol 18(7):1307–1318. 10.1007/s00330-008-0863-7 - PMC - PubMed
    1. Gonzalez V, Arver B, Löfgren L, Bergkvist L, Sandelin K, Eriksson S (2021) Impact of preoperative breast MRI on 10-year survival of patients included in the Swedish randomized multicentre POMB trial. BJS Open 5(5). 10.1093/bjsopen/zrab088 - PMC - PubMed

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